A 68 μg amount of an acyclic polyketide, named beru’amide, was isolated from a marine cyanobacterium Okeania sp. Beru’amide contains six unique moieties in its relatively small skeleton. By applying several cutting-edge techniques, including DFT-based chemical shift calculations, we achieved the structure determination and the total synthesis of this highly functionalized scarce natural product. Furthermore, beru’amide was shown to have strong antitrypanosomal activity.

中文翻译：

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Beru'amide 的分离和全合成，一种来自海洋蓝藻 Okeania sp. 的抗锥体聚酮化合物。

从海洋蓝藻Okeania sp.中分离出 68 μg 的无环聚酮化合物，名为 beru'amide 。Beru'amide 在其相对较小的骨架中包含六个独特的部分。通过应用多种尖端技术，包括基于 DFT 的化学位移计算，我们实现了这种高度功能化的稀有天然产物的结构确定和全合成。此外，beru'amide 被证明具有很强的抗锥虫活性。