Chromosomes in higher eukaryotes are folded at different length scales into loop extrusion domains, spatial compartments, and chromosome territories and exhibit interactions with nuclear structures such as the lamina. Microscopic methods can probe this structure by measuring positions of chromosomes in the nuclear space in individual cells, while sequencing-based contact capture approaches can report the frequency of contacts of different regions within these structural layers. To view this SnapShot, open or download the PDF.

中文翻译：

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快照：染色体组织

高等真核生物中的染色体以不同的长度尺度折叠成环挤压域、空间区室和染色体区域，并表现出与核结构（例如核纤层）的相互作用。显微镜方法可以通过测量单个细胞核空间中染色体的位置来探测这种结构，而基于测序的接触捕获方法可以报告这些结构层内不同区域的接触频率。要查看此快照，请打开或下载 PDF。