Association of long-term exposure to PM2.5 in workplace with fasting plasma glucose among asymptomatic adults: A multicenter study in North China,Environment International

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Association of long-term exposure to PM2.5 in workplace with fasting plasma glucose among asymptomatic adults: A multicenter study in North China
Environment International ( IF 10.3 ) Pub Date : 2022-06-16 , DOI: 10.1016/j.envint.2022.107353
Jiangshan He ₁ , Songhua Hu ₂ , Ximing Xu ₃ , Pei Guo ₁ , Yujie Niu ₄ , Jingbo Zhang ₅ , Rong Zhang ₄ , Shuo Chen ₅ , Shitao Ma ₄ , Feng Liu ₅ , Qiang Li ₅ , Chunjun Li ₆ , Li Zhang ₇ , Ying Wu ₂ , Mianzhi Zhang ₈ , Minying Zhang ₁

Affiliation

Background

The impacts of long-term high exposure to PM_2.5 in workplace on glucose metabolism in asymptomatic working adults (AWAs) have rarely been explored.

Objectives

To assess the relationship between long-term exposure to workplace PM_2.5 and glucose metabolism in asymptomatic general working adults in heavily polluted regions.

Methods

We used the baseline data of the asymptomatic working participants from the Beijing-Tianjin-Hebei Medical Examination Cohort, which recruited adults undergoing medical examinations. A machine learning-based spatial–temporal model was used to estimate daily average PM_2.5 concentrations in the participants’ workplaces. We assessed the association of long-term PM_2.5 concentrations (three years prior to the interview) and fasting plasma glucose (FPG) using generalized linear mixed-effects models (GLMM) with inclusion of potential confounders. Stratified analyses by sex, age, BMI and smoking status, and two pollutant models were further performed.

Results

A total of 37,619 individuals were interviewed and 28,865 were included in the analyses. The mean FPG was 5.20 (0.96) mmol/L, and the estimated three-year average concentration of PM_2.5 exposure was 69.51 (6.92) μg/m³. We detected a significant association of long-term exposure to workplace PM_2.5 and FPG, a 10 µg/m³ increase in the long-term workplace PM_2.5 exposure was associated with 0.075 (95%CI: 0.050–0.100) mmol/L elevated FPG and 25% (OR = 1.25, 95%CI: 1.05–1.50) elevated odds of abnormal fasting glucose metabolism with control of the potential confounding. The detected association between workplace PM_2.5 and FPG metabolism remained significant in males, individuals aged > 44 years, overweight and/or obese people, both smokers and non-smokers, and when NO₂, SO₂, O₃, and CO were included in the model.

Conclusions

Long-term exposure to workplace PM_2.5 was associated with elevated FPG and/or odds of abnormal glucose metabolism among AWAs. Male, middle-aged, overweight and/or obese AWAs were more susceptible to workplace PM_2.5 regardless of smoking status.

中文翻译：

工作场所长期暴露于 PM2.5 与无症状成人空腹血糖的关系：华北地区的多中心研究

背景

很少有人探讨工作场所长期大量接触 PM _{2.5对无症状工作成年人 (AWA) 葡萄糖代谢的影响。}

目标

评估重度污染地区无症状普通工作成年人长期暴露于工作场所PM _{2.5与糖代谢之间的关系。}

方法

我们使用了京津冀体检队列中无症状工作人员的基线数据，该队列招募了接受体检的成年人。基于机器学习的时空模型用于估计参与者工作场所的每日平均 PM _2.5浓度。我们使用广义线性混合效应模型 (GLMM)评估了长期 PM _{2.5浓度（采访前三年）与空腹血糖 (FPG) 的关联，并纳入了潜在的混杂因素。}进一步按性别、年龄、体重指数和吸烟状况以及两种污染物模型进行分层分析。

结果

总共采访了 37,619 人，分析中纳入了 28,865 人。_{平均FPG为5.20（0.96）mmol/L，PM 2.5}暴露的三年平均浓度估计为69.51（6.92）μg/m ³。我们检测到长期暴露于工作场所 PM _2.5和 FPG之间存在显着关联，长期工作场所 PM _2.5暴露增加10 µg/m ³与 0.075 (95%CI: 0.050–0.100) mmol/L 升高相关FPG 和 25%（OR = 1.25，95%CI：1.05–1.50）增加了空腹血糖代谢异常的几率，同时控制了潜在的混杂因素。检测到的工作场所 PM _2.5与 FPG 代谢之间的关联在男性、年龄 > 44 岁的个人、超重和/或肥胖者、吸烟者和非吸烟者中仍然显着，并且当 NO 2 、SO ₂、_O 3_和CO 包括在内时在模型中。