Control of Blood Pressure and Risk of Cardiovascular Disease and Mortality in Elderly Chinese: A Real-World Prospective Cohort Study,Hypertension

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Control of Blood Pressure and Risk of Cardiovascular Disease and Mortality in Elderly Chinese: A Real-World Prospective Cohort Study
Hypertension ( IF 6.9 ) Pub Date : 2022-06-15 , DOI: 10.1161/hypertensionaha.122.19587
Anxin Wang _{1,

2} , Xue Tian _{1,

2,

3,

4} , Yingting Zuo _{1,

2,

3,

4} , Shuohua Chen ₅ , Yijun Zhang _{1,

2} , Xiaoli Zhang _{1,

2} , Xuan Deng ₆ , Qin Xu _{1,

2} , Penglian Wang _{1,

2} , Shouling Wu ₅ , Yong Zhou ₆

Affiliation

Background:The STEP trial (Strategy of Blood Pressure Intervention in the Elderly Hypertensive Patients) showed that older hypertensive patients might benefit from a target systolic blood pressure (SBP) of 110 to <130 mm Hg. We examined whether this target SBP is associated with a decreased risk of cardiovascular disease (CVD) and all-cause mortality among elderly Chinese in real-world settings.Methods:This prospective study included 13 383 CVD-free participants aged 60 to 80 years and with SBP within 110 to <150 mm Hg at baseline. Inverse probability of treatment weighting was used to adjust for baseline differences. Weighted Cox proportional hazards models yielded adjusted hazard ratios (HRs) and 95% CIs of CVD and all-cause mortality associated with normalized SBP (110 to <130 mm Hg).Results:During a median follow-up of 13.01 years, we identified 1727 cases of CVD and 3742 deaths. After inverse probability of treatment weighting, compared with non-normalized SBP, normalized SBP was associated with a decreased risk of CVD (HR, 0.81 [95% CI, 0.76–0.87]) and all-cause mortality (HR, 0.89 [95% CI, 0.85–0.93]). Beneficial effects of longitudinal normalized SBP presented by the updated mean SBP were also observed for CVD (HR, 0.88 [95% CI, 0.78–0.93]) and all-cause mortality (HR, 0.93 [95% CI, 0.88–0.97]). Multiple sensitivity analyses yielded similar results.Conclusions:The SBP target of 110 to <130 mm Hg recommended by the STEP trial was associated a lower risk of CVD and all-cause mortality than was SBP of 130 to <150 mm Hg among elderly Chinese in real-world settings.

更新日期：2022-06-15

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