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A Novel Antineutrophil Extracellular Trap Antibody Targeting Myosin Light Chain 6 in Microscopic Polyangiitis.
The Journal of Rheumatology ( IF 3.6 ) Pub Date : 2022-06-15 , DOI: 10.3899/jrheum.211266
Miku Yoshinari 1 , Fumihiko Hattanda 2 , Yuka Nishibata 1 , Sakiko Masuda 1 , Daigo Nakazawa 2 , Utano Tomaru 3 , Akihiro Ishizu 4
Affiliation  

Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is characterized by ANCA production in the serum. This disease entity includes microscopic polyangiitis (MPA). Previous studies have revealed that neutrophils excessively activated by ANCA and other serum factors are critically involved in AAV pathogenesis1.

中文翻译:

一种新型抗中性粒细胞胞外陷阱抗体,靶向显微镜下多血管炎中的肌球蛋白轻链 6。

抗中性粒细胞胞浆抗体 (ANCA) 相关性血管炎 (AAV) 的特征是血清中产生 ANCA。这种疾病实体包括显微镜下多血管炎 (MPA)。先前的研究表明,ANCA 和其他血清因子过度激活的中性粒细胞在 AAV 发病机制中起着关键作用1
更新日期:2022-06-15
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