In this paper, a lutein-glucosyl stevioside (stevia-G)-hydroxypropyl methylcellulose (HPMC) complex was prepared via an antisolvent precipitation combined with dynamic high pressure microfluidization method. The solubility, microstructure, crystallinity and thermodynamic properties of the freeze-dried powder were investigated, as well as the formation mechanism and the storage stability of the produced complex. When the optimal mass ratio of lutein, stevia-G, and HPMC was 1: 40: 0.5, the apparent solubility of lutein reached 2805.47 ± 24.94 μg·mL⁻¹, which was approximately 5600 times higher than that of lutein crystals. The lutein-stevia-G-HPMC complex formed an amorphous dispersed structure and was in a thermodynamically high energy state. The self-assembled micelle structure of stevia-G and HPMC polymer created a supersaturated system mainly by multiple hydrogen bonding, which promoted maximum lutein dissolving, delayed supersaturated crystallization process, and hindered precipitation. The present results suggested the complex formed by stevia-G and HPMC effectively promote lutein’s hydrophilicity and stability.

本文采用抗溶剂沉淀结合动态高压微流化法制备叶黄素-葡萄糖基甜菊苷（stevia-G）-羟丙基甲基纤维素（HPMC）复合物。研究了冻干粉体的溶解度、微观结构、结晶度和热力学性质，以及制备的复合物的形成机理和储存稳定性。当叶黄素、甜菊糖-G和HPMC的最佳质量比为1:40:0.5时，叶黄素的表观溶解度达到2805.47±24.94 μg·mL ^-1，大约是叶黄素晶体的 5600 倍。叶黄素-甜叶菊-G-HPMC复合物形成无定形分散结构，处于热力学高能态。stevia-G与HPMC聚合物的自组装胶束结构主要通过多个氢键形成过饱和体系，促进叶黄素最大限度溶解，延缓过饱和结晶过程，阻碍沉淀。目前的结果表明，甜菊-G和HPMC形成的复合物有效地促进了叶黄素的亲水性和稳定性。