The antidiabetic potential of bioactive peptides derived from simulated gastrointestinal digestion (SGID) of proteins present in amaranth quinoa and chia was evaluated using their bioactivity profile and theoretical interaction with DPP-IV and α-glucosidases. In silico SGID generated 52 different fragments with in vitro antidiabetic activity where fragments PW, PF, PPG, PM, SW, IW, SF, PP, PPL, PG, PY, VW and PL scored highly in bioactivity probability, with molecular weights ranging from 172.2 to 325.44 Da; positive bulkiness index and hydrophobicity (except PP and PY) and no toxic properties. Fragments IW and PW presented the lowest free energy values for enzymes DPP-IV, maltase-glucoamylase, pancreatic α-amylase and sucrase-isomaltase (-8.2, −7.5, −7.7 and −7.5 kcal/mol; and −7.8, −7.4, −8.2, −7.4 kcal/mol respectively) We can conclude that proteins from amaranth, quinoa and chia may be a good source of antidiabetic BP and may exert antidiabetic activity through the release of BP after digestion.

使用苋菜藜麦和奇亚籽中存在的蛋白质的模拟胃肠消化 (SGID) 衍生的生物活性肽的抗糖尿病潜力通过它们的生物活性谱和与 DPP-IV 和 α-葡萄糖苷酶的理论相互作用进行了评估。在 silico SGID体外生成了 52 个不同的片段抗糖尿病活性，其中片段 PW、PF、PPG、PM、SW、IW、SF、PP、PPL、PG、PY、VW 和 PL 在生物活性概率上得分很高，分子量范围为 172.2 至 325.44 Da；正体积指数和疏水性（PP 和 PY 除外）且无毒性。对于酶 DPP-IV、麦芽糖酶-葡糖淀粉酶、胰腺 α-淀粉酶和蔗糖酶-异麦芽糖酶，IW 和 PW 片段的自由能值最低（-8.2、-7.5、-7.7 和 -7.5 kcal/mol；和 -7.8、-7.4 , -8.2, -7.4 kcal/mol) 我们可以得出结论，来自苋菜、藜麦和奇异子的蛋白质可能是抗糖尿病 BP 的良好来源，并且可能通过消化后释放的 BP 发挥抗糖尿病活性。