A Green Multicomponent Domino Mannich-Michael Reaction to Synthesize Novel Naphthoquinone-Polyphenols with Antiproliferative and Antioxidant Activities,European Journal of Organic Chemistry

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A Green Multicomponent Domino Mannich-Michael Reaction to Synthesize Novel Naphthoquinone-Polyphenols with Antiproliferative and Antioxidant Activities
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2022-06-14 , DOI: 10.1002/ejoc.202200442
Eclair Venturini Filho ₁ , Mariana K Antoniazi ₁ , Rafael Q Ferreira ₁ , Gabriel F. S. dos Santos ₁ , Claudia Pessoa ₂ , Celina J. Guimarães ₂ , José B. Vieira Neto ₂ , Artur M. S. Silva ₃ , Sandro Greco ₄

Affiliation

This work describes a new methodology to synthesize novel naphthoquinone polyphenols. These compounds were submitted to CRAC assays, and, in general, showed antioxidant activities superior to Trolox. In addition, the antiproliferative activity of the most active compounds showed IC₅₀ values for HCT116 and PC3 comparable to those of 5-fluorouracil and superior to doxorubicin in HL60 and SNB19 human cancer cells.

中文翻译：

绿色多组分 Domino Mannich-Michael 反应合成具有抗增殖和抗氧化活性的新型萘醌-多酚

这项工作描述了一种合成新型萘醌多酚的新方法。这些化合物进行了 CRAC 分析，通常显示出优于 Trolox 的抗氧化活性。此外，最活跃的化合物的抗增殖活性显示出对 HCT116 和 PC3 的 IC ₅₀值与 5-氟尿嘧啶相当，并且在 HL60 和 SNB19 人类癌细胞中优于多柔比星。

更新日期：2022-06-14

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