Water dynamics in human cancer and non-cancer tissues,Physical Chemistry Chemical Physics

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Water dynamics in human cancer and non-cancer tissues
Physical Chemistry Chemical Physics ( IF 2.9 ) Pub Date : 2022-06-15 , DOI: 10.1039/d2cp00621a
M P M Marques _{1,

2} , I P Santos ₁ , A L M Batista de Carvalho ₁ , A P Mamede ₁ , C B Martins ₁ , P Figueiredo ₃ , M Sarter ₄ , V García Sakai ₄ , L A E Batista de Carvalho ₁

Affiliation

Normal-to-malignant transformation is a poorly understood process associated with cellular biomechanical properties. These are strongly dependent on the dynamical behaviour of water, known to play a fundamental role in normal cellular activity and in the maintenance of the three-dimensional architecture of the tissue and the functional state of biopolymers. In this study, quasi-elastic neutron scattering was used to probe the dynamical behaviour of water in human cancer specimens and their respective surrounding normal tissue from breast and tongue, as an innovative approach for identifying particular features of malignancy. This methodology has been successfully used by the authors in human cells and was the first study of human tissues by neutron scattering techniques. A larger flexibility was observed for breast versus tongue tissues. Additionally, different dynamics were found for malignant and non-malignant specimens, depending on the tissue: higher plasticity for breast invasive cancer versus the normal, and an opposite effect for tongue. The data were interpreted in the light of two different water populations within the samples: one displaying bulk-like dynamics (extracellular and intracellular/cytoplasmic) and another with constrained flexibility (extracellular/interstitial and intracellular/hydration layers).

中文翻译：

人类癌症和非癌症组织中的水动力学

正常到恶性转化是与细胞生物力学特性相关的一个鲜为人知的过程。这些强烈依赖于水的动态行为，已知水在正常细胞活动和维持组织的三维结构和生物聚合物的功能状态中起着重要作用。在这项研究中，准弹性中子散射被用来探测人类癌症样本中水的动态行为，以及来自乳房和舌头的它们各自的周围正常组织，作为一种识别恶性肿瘤特定特征的创新方法。该方法已被作者成功用于人体细胞，并且是通过中子散射技术对人体组织进行的首次研究。与乳房相比，观察到更大的柔韧性舌组织。此外，根据组织的不同，发现恶性和非恶性标本的动态不同：与正常组织相比，乳腺癌的可塑性更高，而舌头则相反。数据根据样品中两种不同的水群进行解释：一种显示类似体积的动力学（细胞外和细胞内/细胞质），另一种具有受限的灵活性（细胞外/间质和细胞内/水合层）。

更新日期：2022-06-15

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