The layer-by-layer technique (LbL) using polysaccharides is receiving increasing interest as the preparation of nano- and micro- multilayer objects composed by natural materials is a promising alternative for actual systems. The use of bacterial polysaccharides and more particularly, dextrans and dextran derivatives, in LbL assemblies allows the simple formation of biodegradable and biocompatible multilayers with engineered functionalities. The choice of dextrans and derivatives along with the assembly conditions can indeed control internal structure and physical, chemical and biological properties. In this review, we describe the use of dextrans and dextran derivatives into multilayers presented in literature, from the method and principles to the key parameters that need to be considered in their formations. We present their valorisation into nanoobjects with specific and stimuli-responsive properties that are mainly exploited for biomedical applications as drug delivery devices.

使用多糖的逐层技术 (LbL) 受到越来越多的关注，因为由天然材料组成的纳米和微米多层物体的制备是实际系统的一种有前途的替代方案。在 LbL 组件中使用细菌多糖，更具体地说，葡聚糖和葡聚糖衍生物，可以简单地形成具有工程功能的可生物降解和生物相容的多层。葡聚糖及其衍生物的选择以及组装条件确实可以控制内部结构和物理、化学和生物特性。在这篇综述中，我们描述了将葡聚糖和葡聚糖衍生物用于文献中提出的多层膜，从方法和原理到在其形成中需要考虑的关键参数。