The microbiome modulates brain function, but the precise routes of gut-brain communication remain unclear. In a recent issue of Science, Gabanyi et al. discover that hypothalamic GABAergic neurons directly recognize microbial muropeptides via NOD2, leading to reduced neuronal activity, loss of appetite, and aberrant thermoregulation.

中文翻译：

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当大脑感觉到错误时

微生物组调节大脑功能，但肠道-大脑交流的精确途径仍不清楚。在最近一期的《科学》杂志上，Gabanyi 等人。发现下丘脑 GABA 能神经元通过 NOD2 直接识别微生物细胞肽，导致神经元活动减少、食欲不振和体温调节异常。