Metastatic ovarian cancer is a significant clinical challenge due in part to its poor response to immunotherapy. In a recent issue of Cancer Cell, Anandon et al. (2022) identify a population of stem-like tissue-resident memory T cells that are responsible for the bulk of anti-tumor T cell immunity, with insights into improving therapeutic response.

中文翻译：

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小池塘里的大鱼：狭窄的干细胞样组织驻留 T 细胞库在抗肿瘤免疫中产生了巨大的力量

转移性卵巢癌是一项重大的临床挑战，部分原因是其对免疫疗法的反应不佳。在最近一期的Cancer Cell中，Anandon 等人。（2022 年）确定了一组干细胞样组织驻留记忆 T 细胞，这些细胞负责大部分的抗肿瘤 T 细胞免疫，并有助于改善治疗反应。