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A core outcome set for post-COVID-19 condition in adults for use in clinical practice and research: an international Delphi consensus study
The Lancet Respiratory Medicine ( IF 38.7 ) Pub Date : 2022-06-14 , DOI: 10.1016/s2213-2600(22)00169-2
Daniel Munblit 1 , Timothy Nicholson 2 , Athena Akrami 3 , Christian Apfelbacher 4 , Jessica Chen 5 , Wouter De Groote 6 , Janet V Diaz 7 , Sarah L Gorst 8 , Nicola Harman 9 , Alisa Kokorina 10 , Piero Olliaro 11 , Callum Parr 5 , Jacobus Preller 12 , Nicoline Schiess 13 , Jochen Schmitt 14 , Nina Seylanova 15 , Frances Simpson 16 , Allison Tong 17 , Dale M Needham 18 , Paula R Williamson 9 ,
Affiliation  

Health consequences that persist beyond the acute infection phase of COVID-19, termed post-COVID-19 condition (also commonly known as long COVID), vary widely and represent a growing global health challenge. Research on post-COVID-19 condition is expanding but, at present, no agreement exists on the health outcomes that should be measured in people living with the condition. To address this gap, we conducted an international consensus study, which included a comprehensive literature review and classification of outcomes for post-COVID-19 condition that informed a two-round online modified Delphi process followed by an online consensus meeting to finalise the core outcome set (COS). 1535 participants from 71 countries were involved, with 1148 individuals participating in both Delphi rounds. Eleven outcomes achieved consensus for inclusion in the final COS: fatigue; pain; post-exertion symptoms; work or occupational and study changes; survival; and functioning, symptoms, and conditions for each of cardiovascular, respiratory, nervous system, cognitive, mental health, and physical outcomes. Recovery was included a priori because it was a relevant outcome that was part of a previously published COS on COVID-19. The next step in this COS development exercise will be to establish the instruments that are most appropriate to measure these core outcomes. This international consensus-based COS should provide a framework for standardised assessment of adults with post-COVID-19 condition, aimed at facilitating clinical care and research worldwide.



中文翻译:


针对成人 COVID-19 后病情的核心结果集,用于临床实践和研究:一项国际德尔菲共识研究



COVID-19 急性感染阶段之后持续存在的健康后果(称为“后 COVID-19 状况”(也称为“长期 COVID”))差异很大,代表着日益严重的全球健康挑战。关于 COVID-19 后病症的研究正在扩大,但目前对于该病症患者应测量的健康结果尚未达成一致。为了解决这一差距,我们进行了一项国际共识研究,其中包括对 COVID-19 后病情结果的全面文献回顾和分类,为两轮在线修改德尔菲流程提供信息,然后召开在线共识会议以最终确定核心结果集(COS)。来自 71 个国家的 1535 名参与者参与其中,其中两轮 Delphi 轮次都有 1148 人参加。十一项成果达成共识,纳入最终 COS:疲劳;疼痛;劳累后症状;工作或职业和学习的变化;生存;以及心血管、呼吸系统、神经系统、认知、心理健康和身体结果的功能、症状和状况。恢复被预先包含在内,因为它是相关结果,是之前发布的关于 COVID-19 的 COS 的一部分。 COS 开发活动的下一步将是建立最适合衡量这些核心成果的工具。这个基于国际共识的 COS 应该为患有 COVID-19 后病情的成年人提供标准化评估框架,旨在促进全球临床护理和研究。

更新日期:2022-06-14
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