Intelligent Supramolecular Nanoprodrug Based on Anionic Water-Soluble [2]Biphenyl-Extended-Pillar[6]arenes for Combination Therapy,ACS Macro Letters

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Intelligent Supramolecular Nanoprodrug Based on Anionic Water-Soluble [2]Biphenyl-Extended-Pillar[6]arenes for Combination Therapy
ACS Macro Letters ( IF 5.1 ) Pub Date : 2022-06-14 , DOI: 10.1021/acsmacrolett.2c00322
Yue Ding ₁ , Wei Yu ₁ , Jian Wang ₁ , Yuxuan Ma ₁ , Chenwei Wang ₁ , Yang Wang ₁ , Bing Lu ₁ , Yong Yao ₁

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An anionic water-soluble [2]biphenyl-extended-pillar[6]arenes modified with eight ammonium salt ions (AWBpP6) was successfully synthesized to establish a drug–drug conjugate supramolecular nanoprodrug (SNP) with a high drug-loading capacity. This SNP can generate a synergistic triple therapeutic effect of photodynamic therapy (PDT), photothermal therapy (PTT), and chemotherapy (CT; i.e., PDT–PTT-CT) with excellent biocompatibility.

中文翻译：

基于阴离子水溶性[2]联苯延伸柱[6]芳烃的智能超分子纳米前药联合治疗

成功合成了一种用 8 个铵盐离子（AWBpP6）修饰的阴离子水溶性 [2] 联苯延长柱 [6] 芳烃，以建立具有高载药能力的药物-药物偶联超分子纳米前药（SNP）。该SNP可以产生光动力疗法(PDT)、光热疗法(PTT)和化学疗法(CT；即PDT-PTT-CT)的协同三联治疗效果，具有优异的生物相容性。

更新日期：2022-06-14

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