In this issue, Harris et al. (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202203095) show that phosphofructokinase is a substrate for ubiquitination by Fbxo7, a key protein in the ubiquitination pathway. Their findings point to a new interplay between metabolic enzyme degradation in the regulation of T cells.

中文翻译：

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泛素化 T 细胞代谢途径

在本期中，哈里斯等人。 (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202203095) 表明磷酸果糖激酶是 Fbxo7 泛素化的底物，Fbxo7 是泛素化途径中的关键蛋白。他们的发现指出了 T 细胞调节中代谢酶降解之间的新相互作用。