Wang et al. report in this issue (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202108015) that the SARS-CoV-2 protein ORF10 increases the activity of the E3 ligase CUL2ZYG11B, leading to the degradation of multiple ciliary proteins. The resulting loss of cilia may facilitate the spread of SARS-CoV-2 in the respiratory tree.

中文翻译：

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近距离观察：SARS-CoV-2 如何导致纤毛丧失

王等人。本期报告（2022. J. Cell Biol.https://doi.org/10.1083/jcb.202108015）指出，SARS-CoV-2蛋白ORF10增加了E3连接酶CUL2ZYG11B的活性，导致多个纤毛蛋白。由此产生的纤毛损失可能会促进 SARS-CoV-2 在呼吸树中的传播。