The Nuclear Casein and Cyclin-dependent Kinase Substrate 1 (NUCKS1) protein is highly conserved in vertebrates, predominantly localized to the nucleus and one of the most heavily modified proteins in the human proteome. NUCKS1 expression is high in stem cells and the brain, developmentally regulated in mice and associated with several diverse malignancies in humans, including cancer, metabolic syndrome and Parkinson's disease. NUCKS1 function has been linked to modulating chromatin architecture and transcription, DNA repair and cell cycle regulation. In this review, we summarize and discuss the published information on NUCKS1 and highlight the questions that remain to be addressed to better understand the complex biology of this multifaceted protein.

中文翻译：

---

NUCKS1 是一种高度修饰的染色质相关蛋白，参与多种生物和病理生理过程。

核酪蛋白和细胞周期蛋白依赖性激酶底物 1 (NUCKS1) 蛋白在脊椎动物中高度保守，主要定位于细胞核，是人类蛋白质组中修饰最重的蛋白质之一。NUCKS1 在干细胞和大脑中表达很高，在小鼠中受到发育调节，并与人类的几种不同恶性肿瘤相关，包括癌症、代谢综合征和帕金森病。NUCKS1 功能与调节染色质结构和转录、DNA 修复和细胞周期调节有关。在这篇综述中，我们总结和讨论了关于 NUCKS1 的已发表信息，并强调了仍有待解决的问题，以更好地理解这种多面蛋白的复杂生物学。