Piezotronic Effect-Augmented Cu2–xO–BaTiO3 Sonosensitizers for Multifunctional Cancer Dynamic Therapy,ACS Nano

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Piezotronic Effect-Augmented Cu2–xO–BaTiO3 Sonosensitizers for Multifunctional Cancer Dynamic Therapy
ACS Nano ( IF 15.8 ) Pub Date : 2022-06-14 , DOI: 10.1021/acsnano.2c01968
Yunchao Zhao _{1,

2} , Shaobo Wang _{1,

2} , Yiming Ding _{1,

2} , Zeyu Zhang _{1,

2} , Tian Huang _{1,

2} , Yalong Zhang _{1,

2} , Xingyi Wan _{2,

3} , Zhong Lin Wang _{1,

2,

3,

4} , Linlin Li _{1,

2,

3}

Affiliation

Ultrasound (US)-triggered sonodynamic therapy (SDT) based on semiconductor nanomaterials has attracted considerable attention for cancer therapy. However, most inorganic sonosensitizers suffer from low efficiency due to the rapid recombination of electron–hole pairs. Herein, the Cu_2–xO–BaTiO₃ piezoelectric heterostructure was fabricated as a sonosensitizer and chemodynamic agent, simultaneously, for improving reactive oxygen species (ROS) generation and cancer therapeutic outcome. Under US irradiation, the Cu_2–xO–BaTiO₃ heterojunction with a piezotronic effect exhibits high-performance singlet oxygen (¹O₂) and hydroxyl radical (•OH) generation to enhance SDT. Moreover, it possesses Fenton-like reaction activity to convert endogenous H₂O₂ into •OH for chemodynamic therapy (CDT). The integration of SDT and CDT substantially boosts ROS generation and cellular mitochondria damage, and the in vitro and in vivo results demonstrate high cytotoxicity and tumor inhibition on murine refractory breast cancer. This work realizes improvement in cancer therapy using piezoelectric heterostructures with piezotronic effects.

中文翻译：

用于多功能癌症动态治疗的压电效应增强 Cu2–xO–BaTiO3 声敏剂

基于半导体纳米材料的超声（US）触发的声动力疗法（SDT）在癌症治疗中引起了相当大的关注。然而，大多数无机声敏剂由于电子-空穴对的快速复合而效率低下。在此，Cu _{2– x} O–BaTiO ₃压电异质结构被制造为声敏剂和化学动力学剂，同时用于改善活性氧 (ROS) 的生成和癌症治疗结果。在US辐照下，具有压电效应的Cu _{2– x} O–BaTiO ₃异质结表现出高性能的单线态氧（¹ O ₂) 和羟基自由基 (•OH) 的产生以增强 SDT。此外，它具有类芬顿反应活性，可将内源性 H ₂ O ₂转化为•OH，用于化学动力学治疗 (CDT)。SDT 和 CDT 的整合大大促进了 ROS 的产生和细胞线粒体损伤，体外和体内结果表明对小鼠难治性乳腺癌具有高细胞毒性和肿瘤抑制作用。这项工作使用具有压电效应的压电异质结构实现了癌症治疗的改进。

更新日期：2022-06-14

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