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Sugar-induced self-assembly of curcumin-based polydopamine nanocapsules with high loading capacity for dual drug delivery
Nanoscale ( IF 5.8 ) Pub Date : 2022-06-14 , DOI: 10.1039/d2nr01795d Sandy Wong 1 , Cheng Cao 1 , Martina Lessio 1 , Martina H Stenzel 1
Nanoscale ( IF 5.8 ) Pub Date : 2022-06-14 , DOI: 10.1039/d2nr01795d Sandy Wong 1 , Cheng Cao 1 , Martina Lessio 1 , Martina H Stenzel 1
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Many drug delivery carriers reported in the literature require multistep assembly or often have very low drug loading capacities. Here, we present a simple sugar-based strategy that feeds the increased interest in high-loading nanomedicine. The driving force of the supramolecular nanocapsule formation is the interaction between curcumin (CCM) and the monosaccharide fructose. Drug and sugar are simply mixed in an aqueous solution in an open vessel, followed by coating the nanocapsules with polydopamine (PDA) to maintain structural integrity. We show that nanocapsules can still be obtained when other drugs are added, producing dual-drug nanoparticles with sizes of around 150–200 nm and drug loading contents of around 90% depending on the thickness of the PDA shell. This concept is widely applicable for a broad variety of drugs, as long as the drug has similar polarities to CCM. The key to success is the interaction of CCM and the second drug as shown in computational studies. The drug was able to be released from the nanocapsule at a release rate that could be fine-tuned by adjusting the thickness of the PDA layer.
中文翻译：
姜黄素基聚多巴胺纳米胶囊的糖诱导自组装具有高负载能力的双重给药
文献中报道的许多药物输送载体需要多步组装或通常具有非常低的载药能力。在这里，我们提出了一种简单的基于糖的策略，可以满足人们对高负荷纳米药物的兴趣。超分子纳米胶囊形成的驱动力是姜黄素（CCM）和单糖果糖之间的相互作用。药物和糖在开放容器中的水溶液中简单地混合，然后用聚多巴胺 (PDA) 涂覆纳米胶囊以保持结构完整性。我们表明，当添加其他药物时，仍然可以获得纳米胶囊，产生尺寸约为 150-200 nm 的双药纳米颗粒，载药量约为 90%，具体取决于 PDA 壳的厚度。这一概念广泛适用于多种药物，只要药物具有与 CCM 相似的极性。如计算研究所示，成功的关键是 CCM 和第二种药物的相互作用。药物能够以可以通过调整 PDA 层的厚度来微调的释放速率从纳米胶囊中释放出来。
更新日期：2022-06-14
中文翻译：
姜黄素基聚多巴胺纳米胶囊的糖诱导自组装具有高负载能力的双重给药
文献中报道的许多药物输送载体需要多步组装或通常具有非常低的载药能力。在这里，我们提出了一种简单的基于糖的策略，可以满足人们对高负荷纳米药物的兴趣。超分子纳米胶囊形成的驱动力是姜黄素（CCM）和单糖果糖之间的相互作用。药物和糖在开放容器中的水溶液中简单地混合，然后用聚多巴胺 (PDA) 涂覆纳米胶囊以保持结构完整性。我们表明，当添加其他药物时，仍然可以获得纳米胶囊，产生尺寸约为 150-200 nm 的双药纳米颗粒，载药量约为 90%，具体取决于 PDA 壳的厚度。这一概念广泛适用于多种药物，只要药物具有与 CCM 相似的极性。如计算研究所示，成功的关键是 CCM 和第二种药物的相互作用。药物能够以可以通过调整 PDA 层的厚度来微调的释放速率从纳米胶囊中释放出来。
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