Atopic dermatitis (AD) is a chronic inflammatory skin disorder that affects a substantial number of children and has a significant negative impact on affected patients and their caregivers/families. Recent studies have led to significant evolutions in the understanding of AD pathogenesis, epidemiology, and treatment. The first point of contact for many patients with new-onset AD is usually with their primary care provider or pediatrician. This underscores the importance for pediatricians to understand the basic pathophysiology and current standards of care for AD. This article provides up-to-date information and reviews the basic principles of AD pathophysiology, diagnosis, and management. In addition, the article highlights recent advances in scientific research regarding the mechanisms involved in the pathogenesis of atopic dermatitis that have resulted in the discovery of novel therapeutic targets and the development of targeted biologic therapies with the potential to revolutionize AD therapy.

特应性皮炎 (AD) 是一种慢性炎症性皮肤病，影响大量儿童，并对受影响的患者及其护理人员/家人产生重大负面影响。最近的研究导致对 AD 发病机制、流行病学和治疗的理解发生了重大变化。许多新发 AD 患者的第一个联系点通常是他们的初级保健提供者或儿科医生。这强调了儿科医生了解 AD 的基本病理生理学和当前护理标准的重要性。本文提供最新信息并回顾 AD 病理生理学、诊断和管理的基本原则。此外，