Longitudinal Assessment of SARS-CoV-2-Specific T Cell Cytokine-Producing Responses for 1 Year Reveals Persistence of Multicytokine Proliferative Responses, with Greater Immunity Associated with Disease Severity,Journal of Virology

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Longitudinal Assessment of SARS-CoV-2-Specific T Cell Cytokine-Producing Responses for 1 Year Reveals Persistence of Multicytokine Proliferative Responses, with Greater Immunity Associated with Disease Severity
Journal of Virology ( IF 4.0 ) Pub Date : 2022-06-14 , DOI: 10.1128/jvi.00509-22
Jonah Lin ₁ , Ryan Law ₁ , Chapin S Korosec ₂ , Christine Zhou ₁ , Wan Hon Koh _{1,

3} , Mohammad Sajjad Ghaemi ₄ , Philip Samaan _{3,

5} , Hsu Kiang Ooi ₄ , Vitaliy Matveev ₃ , FengYun Yue ₃ , Anne-Claude Gingras _{6,

7} , Antonio Estacio ₈ , Megan Buchholz ₉ , Patti Lou Cheatley ₉ , Avid Mohammadi ₃ , Rupert Kaul ₃ , Katerina Pavinski ₁₀ , Samira Mubareka ₁₁ , Allison J McGeer ₆ , Jerome A Leis ₁₁ , Jane M Heffernan ₂ , Mario Ostrowski _{1,

3,

5,

8,

12}

Affiliation

Department of Immunology, University of Torontogrid.17063.33, Toronto, Ontario, Canada.
Modelling Infection and Immunity Lab, Centre for Disease Modelling, Department of Mathematics and Statistics, York Universitygrid.21100.32, Toronto, Ontario, Canada.
Department of Medicine, University of Torontogrid.17063.33, Toronto, Ontario, Canada.
Digital Technologies Research Centre, National Research Council Canadagrid.24433.32, Toronto, Ontario, Canada.
Department of Laboratory Medicine and Pathobiology, University of Torontogrid.17063.33, Toronto, Ontario, Canada.
Lunenfeld-Tanenbaum Research Institute at Mt. Sinai Hospital, Sinai Health System, Toronto, Ontario, Canada.
Department of Medical Genetics, University of Torontogrid.17063.33, Toronto, Ontario, Canada.
Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Unity Health, Toronto, Ontario, Canada.
Apheresis Unit, Kidney and Metabolism Program, St. Michael's Hospital, Unity Health, Toronto, Ontario, Canada.
Department of Laboratory Medicine, St. Michael's Hospital, Unity Health, Toronto, Ontario, Canada.
Sunnybrook Health Sciences Centre and Research Institute, Toronto, Ontario, Canada.
Institute of Medical Science, University of Torontogrid.17063.33, Toronto, Ontario, Canada.