Abstract

Objective

Examine prospective relationships between erectile dysfunction (ED) drugs and CD4 and CD8 T-cells, and immune markers among men who have sex with men (MSM).

Methods

Data from Multicenter AIDS Cohort Study, an observational prospective cohort study, with semiannual follow-ups conducted in four U.S. centers from 1998 onwards was used. Marginal structural models using g-computation were fitted to estimate the mean differences for the effects of self-reported ED drug use on CD4 and CD8 T-cell outcomes and immune biomarkers.

Results

Total of 1,391 men with HIV (MWH) and 307 men without HIV (MWOH) was included. Baseline mean CD4 cell count among MWH and MWOH was 499.9 and 966.7 cells/μL, respectively. At baseline, 41.8% of MWH were virally suppressed. ED drug users reported a mean of 44.4 months of exposure to ED drugs. ED drug use was associated with increased CD4 cell outcomes among MWH but not MWOH. Mean differences in CD4 cell counts after 1 year of ED drug use was 57.6 cells/μL and increased to 117.7 after 10 years among MWH. CD8 counts were higher in ED drug users among MWH over 10 years than non-users; no consistent differences were found among MWOH. ED drug use appeared to reduce immune marker levels, such as IL-6 and increase markers, such as IL-10. We observed similar effects of ED drug use on biomarker levels among MWOH.

Conclusion

Long-term use of ED drugs do not adversely affect immune function among MWH or MWOH. Future studies on the relationships between different types of ED drugs and effects on T-cell subtypes are warranted.

中文翻译：

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使用勃起功能障碍药物对男男性行为者 T 细胞和免疫标志物的影响

 抽象的

 客观的

检查勃起功能障碍 (ED) 药物与 CD4 和 CD8 T 细胞以及男男性行为者 (MSM) 中的免疫标志物之间的前瞻性关系。

 方法

使用多中心艾滋病队列研究的数据，这是一项观察性前瞻性队列研究，自 1998 年起在美国四个中心每半年进行一次随访。使用 g 计算的边际结构模型用于估计自我报告的 ED 药物使用对 CD4 和 CD8 T 细胞结果和免疫生物标志物影响的平均差异。

 结果

总共包括 1,391 名感染艾滋病毒的男性 (MWH) 和 307 名未感染艾滋病毒的男性 (MWOH)。 MWH 和 MWOH 的基线平均 CD4 细胞计数分别为 499.9 和 966.7 个细胞/μL。基线时，41.8% 的 MWH 受到病毒抑制。 ED 药物使用者报告平均 44.4 个月接触 ED 药物。 ED 药物的使用与 MWH 中 CD4 细胞结果增加相关，但与 MWOH 无关。使用 ED 药物 1 年后，MWH 中 CD4 细胞计数的平均差异为 57.6 个细胞/μL，10 年后增加至 117.7 个细胞/μL。 10 年来，MWH 中 ED 吸毒者的 CD8 计数高于非吸毒者； MWOH 之间没有发现一致的差异。 ED 药物的使用似乎会降低免疫标志物水平，例如 IL-6，并增加标志物水平，例如 IL-10。我们在 MWOH 中观察到 ED 药物使用对生物标志物水平的类似影响。

 结论

长期使用 ED 药物不会对 MWH 或 MWOH 的免疫功能产生不利影响。未来有必要研究不同类型 ED 药物之间的关系以及对 T 细胞亚型的影响。