Network pharmacology provides a systematic approach to understanding the treatment of ischemic heart diseases with traditional Chinese medicine,Phytomedicine

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Network pharmacology provides a systematic approach to understanding the treatment of ischemic heart diseases with traditional Chinese medicine
Phytomedicine ( IF 6.7 ) Pub Date : 2022-06-12 , DOI: 10.1016/j.phymed.2022.154268
Hua-Yi Yang ₁ , Men-Lan Liu ₂ , Pei Luo ₁ , Xin-Sheng Yao ₃ , Hua Zhou ₄

Affiliation

Faculty of Chinese Medicine and State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macao, P R China; Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China, Macau University of Science and Technology, Taipa, Macao, P R China.
Faculty of Chinese Medicine and State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macao, P R China; Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China, Macau University of Science and Technology, Taipa, Macao, P R China; National Traditional Chinese Medicine Clinical Research Base and Department of Cardiovascular Medicine, Hospital (T.C.M) Affiliated to Southwest Medical University, Luzhou, Sichuan, P R China.
Faculty of Chinese Medicine and State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macao, P R China; Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou, Guangdong, China.
Faculty of Chinese Medicine and State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macao, P R China; Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China, Macau University of Science and Technology, Taipa, Macao, P R China; Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, P R China; Zhuhai Hospital of Integrated Traditional Chinese and Western Medicine, Zhuhai, Guangdong Province, P R China; Guangdong Provincial Hospital of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, State Key Laboratory of Dampness Syndrome of Chinese Medicine, Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, P R China.

Background

The field of network pharmacology showed significant development. The concept of network pharmacology has many similarities to the philosophy of traditional Chinese medicine (TCM), making it suitable to understand the action mechanisms of TCM in treating complex diseases, such as ischemic heart diseases (IHDs).

Purpose

This review summarizes the representative applications of network pharmacology in deciphering the mechanism underlying the treatment of IHDs with TCM.

Methods

In this report, we used “ischemic heart disease” OR “coronary heart disease” OR “coronary artery disease” OR “myocardial ischemia” AND (“network pharmacology” OR “systematic pharmacology”) as keywords to search for publications from PubMed, the Web of Science, and Google Scholar databases and then analyzed the representative research reports that summarized and validated the active components and targets network of TCM in improving IHDs to show the advantages and deficiencies of network pharmacology applied in TCM research.

Results

The network pharmacology research indicated that HGF, PGF, MMP3, INSR, PI3K, MAPK1, SRC, VEGF, VEGFR-1, NO, eNOS, NO3, IL-6, TNF-α, and more are the main targets of TCM. Apigenin, 25S-macrostemonoside P, ginsenosides Re, Rb3, Rg3, SheXiang XinTongNing, colchicine, dried ginger-aconite decoction, Suxiao Xintong dropping pills, Ginseng-Danshen drug pair and Shenlian and more are the active ingredients, extracts, and formulations of TCM to ameliorate IHDs. These active compounds, extract, and formulations of TCM treat IHDs by delaying ventricular remodeling, reducing myocardial fibrosis, decreasing reactive oxygen species, regulating myocardial energy metabolism, ameliorating inflammation, mitigating apoptosis, and many other aspects.

Conclusions

The network pharmacology supplies a novel research exemplification for understanding the treatment of IHDs with TCM. However, the application of network pharmacology in TCM studies is still at a superficial level. By rational combining artificial intelligence technology and network pharmacology, molecular biology, metabolomics, and other advanced theories and technologies, and systematically studying the metabolic process and the network among products, targets, and pathways of TCM from the clinical perspective may be a potential development trend in network pharmacology.

中文翻译：

网络药理学为理解中医药治疗缺血性心脏病提供了系统的方法

背景

网络药理学领域发展显着。网络药理学的概念与中医哲学有许多相似之处，使其适合理解中医治疗复杂疾病的作用机制，例如缺血性心脏病（IHDs）。

目的

本综述总结了网络药理学在破译中医药治疗 IHD 机制中的代表性应用。

方法

在本报告中，我们使用“缺血性心脏病”或“冠心病”或“冠状动脉疾病”或“心肌缺血”和（“网络药理学”或“系统药理学”）作为关键词来搜索来自 PubMed 的出版物， Web of Science 和 Google Scholar 数据库，然后对代表性研究报告进行了分析，总结和验证了中医药在改善 IHD 中的活性成分和靶点网络，以展示网络药理学应用于中医药研究的优势和不足。

结果

网络药理学研究表明，HGF、PGF、MMP3、INSR、PI3K、MAPK1、SRC、VEGF、VEGFR-1、NO、eNOS、NO3、IL-6、TNF-α等是中药的主要靶点。芹菜素、25S-大香果苷P、人参皂甙、Rb3、Rg3、蛇香心痛宁、秋水仙碱、干姜附子汤、速消心痛滴丸、人参丹参药对、参连等是中药的有效成分、提取物和剂型改善 IHD。这些中药活性化合物、提取物和制剂通过延缓心室重构、减少心肌纤维化、减少活性氧物质、调节心肌能量代谢、改善炎症、减轻细胞凋亡和许多其他方面来治疗 IHD。