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Development and optimization of the novel scale-up fabrication method of polyvinylpyrrolidone (PVP) microparticles
Journal of Electrostatics ( IF 1.9 ) Pub Date : 2022-06-11 , DOI: 10.1016/j.elstat.2022.103725
Afsaneh Valipouri , Hajar Hosseinian , Seyed Abdolkarim Hosseini Ravandi , Afifeh Karimian

This research proposed a new method for making polymer microparticles. Polyvinylpyrrolidone was used in concentrations of 1–5%. First, the critical conditions of microparticles were evaluated through the electrocentrifuge spinning system. The critical voltage, rotating speed, and solution concentration were obtained. The results showed that the number of particles increased in each solution concentration and the particle size decreased with increasing the voltage. Also, as the rotating speed increases, the particles reach the bed before drying, thus sticking to each other and creating a smooth surface. However, at high voltages, the particles stick less to each other.



中文翻译:

新型聚乙烯吡咯烷酮(PVP)微粒放大制备方法的开发与优化

该研究提出了一种制备聚合物微粒的新方法。聚乙烯吡咯烷酮的使用浓度为 1-5%。首先,通过电离心旋转系统评估微粒的临界条件。获得了临界电压、转速和溶液浓度。结果表明,随着电压的升高,各溶液浓度下颗粒数量增加,粒径减小。此外,随着转速的增加,颗粒在干燥前到达床层,从而相互粘附并形成光滑的表面。然而,在高电压下,颗粒彼此之间的粘附较少。

更新日期:2022-06-14
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