Inappropriate Sinus Tachycardia: Etiology, Pathophysiology, and Management: JACC Review Topic of the Week,Journal of the American College of Cardiology

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Inappropriate Sinus Tachycardia: Etiology, Pathophysiology, and Management: JACC Review Topic of the Week
Journal of the American College of Cardiology ( IF 21.7 ) Pub Date : 2022-06-13 , DOI: 10.1016/j.jacc.2022.04.019
Adnan Ahmed ₁ , Naga Venkata K Pothineni ₁ , Rishi Charate ₁ , Jalaj Garg ₂ , Mehmet Elbey ₁ , Carlo de Asmundis ₃ , Mark LaMeir ₃ , Ahmed Romeya ₁ , Poojita Shivamurthy ₁ , Brian Olshansky ₄ , Andrea Russo ₅ , Rakesh Gopinathannair ₁ , Dhanunjaya Lakkireddy ₁

Affiliation

Inappropriate sinus tachycardia (IST) is a clinical syndrome that generally affects young patients and is associated with distressing symptoms. Although the most common symptom is palpitations, it can be accompanied by a myriad of symptoms, including anxiety, dizziness, presyncope, and syncope. The pathogenesis of IST is not well understood and considered multifactorial, with autonomic dysfunction being the central abnormality. IST is a diagnosis of exclusion. Management presents a clinical challenge. The overall efficacy of lifestyle modifications and medical therapy may be limited. Recent advances in catheter and surgical sinus node sparing ablation techniques have led to improvement in outcomes. In addition, increased focus has led to development of multimodality team-based interventions to improve outcomes in this group of patients. In this review, we discuss the mechanistic basis of IST, review current approaches to diagnosis, and outline contemporary therapeutic approaches.

中文翻译：

不适当的窦性心动过速：病因学、病理生理学和治疗：JACC 本周评论主题

不适当窦性心动过速 (IST) 是一种临床综合征，通常影响年轻患者，并伴有令人痛苦的症状。虽然最常见的症状是心悸，但它也可能伴有多种症状，包括焦虑、头晕、先兆晕厥和晕厥。 IST 的发病机制尚不清楚，被认为是多因素的，其中自主神经功能障碍是主要异常。 IST 是一种排除诊断。管理提出了临床挑战。生活方式改变和药物治疗的总体疗效可能有限。导管和手术窦房结保留消融技术的最新进展已导致结果的改善。此外，更多的关注导致了基于团队的多模式干预措施的开发，以改善这组患者的预后。在这篇综述中，我们讨论了 IST 的机制基础，回顾了当前的诊断方法，并概述了当代的治疗方法。

更新日期：2022-06-13

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