Background

Previous studies have focused on the involvement of small nucleolar RNAs (snoRNAs) and SNHGs in tumor cell proliferation, apoptosis, invasion, and metastasis via multiple pathways, including phosphatidylinositol-3-kinase/protein kinase B (PI3K/AKT), Wnt/β catenin, and mitogen-activated protein kinase (MAPK). These molecular mechanisms affect the integrity of the intestinal mucosal barrier.

Aim of review

Current evidence regarding snoRNAs and SNHGs in the context of the mucosal barrier and modulation of homeostasis is fragmented. In this review, we collate the established information on snoRNAs and SNHGs as well as discuss the major pathways affecting the mucosal barrier.

Key scientific concepts of review

Intestinal mucosal immunity, microflora, and the physical barrier are altered in non-neoplastic diseases such as inflammatory bowel diseases. Dysregulated snoRNAs and SNHGs may impact the intestinal mucosal barrier to promote the pathogenesis and progression of multiple diseases. SnoRNAs or SNHGs has been shown to be associated with poor disease behaviors, indicating that they may be exploited as prognostic biomarkers. Additionally, clarifying the complicated interactions between snoRNAs or SNHGs and the mucosal barrier may provide novel insights for the therapeutic treatment targeting strengthen the intestinal mucosal barrier.

中文翻译：

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肠粘膜屏障中的小核仁 RNA 和 SNHG：新兴见解和当前作用

背景

以前的研究主要集中在小核仁 RNA (snoRNA) 和 SNHG 通过多种途径参与肿瘤细胞增殖、凋亡、侵袭和转移，包括磷脂酰肌醇-3-激酶/蛋白激酶 B (PI3K/AKT)、Wnt/β连环蛋白和丝裂原活化蛋白激酶 (MAPK)。这些分子机制影响肠粘膜屏障的完整性。

审查目的

目前关于粘膜屏障和体内平衡调节的 snoRNA 和 SNHG 的证据是零散的。在这篇综述中，我们整理了关于 snoRNA 和 SNHG 的既定信息，并讨论了影响粘膜屏障的主要途径。

综述的关键科学概念

肠道粘膜免疫、微生物群落和物理屏障在非肿瘤性疾病（如炎症性肠病）中发生改变。失调的 snoRNA 和 SNHG 可能影响肠粘膜屏障，从而促进多种疾病的发病机制和进展。SnoRNA 或 SNHG 已被证明与不良疾病行为有关，表明它们可能被用作预后生物标志物。此外，阐明 snoRNA 或 SNHG 与粘膜屏障之间复杂的相互作用可能为靶向强化肠粘膜屏障的治疗提供新的见解。