Synthesis of Azepinoindoles via Pd-Catalyzed C(sp2)–H Imidoylative Cyclization Reactions,The Journal of Organic Chemistry

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Synthesis of Azepinoindoles via Pd-Catalyzed C(sp2)–H Imidoylative Cyclization Reactions
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2022-06-13 , DOI: 10.1021/acs.joc.2c00717
Jiang Wang ₁ , Pinzhuo Ren ₁ , Gongping Gu ₁ , Zongyou Jiang ₁ , Bolin Xiang ₁ , Shi Tang _{1,

2} , Ai-Qun Jia ₁

Affiliation

An efficient and convenient method for the construction of diverse free (N–H)-benzazepinoindoles by Pd-catalyzed C(sp²)-H imidoylative cyclization of 3-(2-isocyanobenzyl)-1H-indoles was developed. The reaction shows a wide substrate scope and can be scaled up, providing a practical route to valuable bioactive azepinoindoles.

中文翻译：

Pd催化的C(sp2)-H亚氨基环化反应合成氮杂吲哚

^{开发了一种通过 Pd 催化的 C(sp 2} )-H 亚胺酰环化 3-(2-isocyanobenzyl)-1 H -indoles构建多种游离 (N-H)-苯并氮杂吲哚的高效便捷方法。该反应显示出广泛的底物范围并且可以放大，为有价值的生物活性氮杂吲哚提供了一条实用的途径。

更新日期：2022-06-13

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