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Micromotor-Assisted Keratinocytes Migration in a Floating Paper Chip
Small ( IF 13.0 ) Pub Date : 2022-06-13 , DOI: 10.1002/smll.202201251 Paula de Dios Andres 1 , Brigitte Städler 1
Small ( IF 13.0 ) Pub Date : 2022-06-13 , DOI: 10.1002/smll.202201251 Paula de Dios Andres 1 , Brigitte Städler 1
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In vitro epidermis models are important to evaluate and study disease progression and possible dermal drug delivery. An in vitro epidermis model using floating paper chips as a scaffold for proliferation and differentiation of primary human keratinocytes is reported. The formation of the four main layers of the epidermis (i.e., basal, spinosum, granulose, and cornified layers) is confirmed. The development of a cornified layer and the tight junction formation are evaluated as well as the alterations of organelles during the differentiation process. Further, this in vitro model is used to assess keratinocyte migration. Finally, magnetic micromotors are assembled, and their ability to aid cell migration on paper chips is confirmed when a static magnetic field is present. Taken together, this attempt to combine bottom-up synthetic biology with dermatology offers interesting opportunities for studying skin disease pathologies and evaluate possible treatments.
中文翻译：
微电机辅助角质形成细胞在浮动纸芯片中的迁移
体外表皮模型对于评估和研究疾病进展和可能的皮肤药物输送很重要。报道了一种体外表皮模型，它使用漂浮纸片作为原代人角质形成细胞增殖和分化的支架。确认了表皮的四个主要层（即基底层、棘层、颗粒层和角化层）的形成。评估了角化层的发育和紧密连接的形成以及细胞器在分化过程中的变化。此外，该体外模型用于评估角质形成细胞迁移。最后，组装磁性微电机，并在存在静磁场时确认它们有助于细胞在纸芯片上迁移的能力。综合起来，
更新日期：2022-06-13
中文翻译：
微电机辅助角质形成细胞在浮动纸芯片中的迁移
体外表皮模型对于评估和研究疾病进展和可能的皮肤药物输送很重要。报道了一种体外表皮模型，它使用漂浮纸片作为原代人角质形成细胞增殖和分化的支架。确认了表皮的四个主要层（即基底层、棘层、颗粒层和角化层）的形成。评估了角化层的发育和紧密连接的形成以及细胞器在分化过程中的变化。此外，该体外模型用于评估角质形成细胞迁移。最后，组装磁性微电机，并在存在静磁场时确认它们有助于细胞在纸芯片上迁移的能力。综合起来，
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