Glucose-Activated Nanoconfinement Supramolecular Cascade Reaction in Situ for Diabetic Wound Healing,ACS Nano

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Glucose-Activated Nanoconfinement Supramolecular Cascade Reaction in Situ for Diabetic Wound Healing
ACS Nano ( IF 15.8 ) Pub Date : 2022-06-13 , DOI: 10.1021/acsnano.2c04566
Lei Chen _{1,

2} , Yong Chen ₁ , Rong Zhang ₁ , Qilin Yu ₃ , Yong Liu ₂ , Yu Liu _{1,

4,

5}

Affiliation

Supramolecular nanofunctional materials have attracted increasing attention from scientific researchers due to their advantages in biomedicine. Herein, we construct a nanosupramolecular cascade reactor through the cooperative interaction of multiple noncovalent bonds, which include chitosan, sulfobutylether-β-cyclodextrin, ferrous ions, and glucose oxidase. Under the activation of glucose, hydroxyl radicals generated from the nanoconfinement supramolecular cascade reaction process are able to initiate the radical polymerization process of vinyl monomers to form hydrogel network structures while inhibiting resistant bacterial infection. The results of the diabetic wound experiment confirmed the capacity of the glucose-activated nanoconfinement supramolecular cascade reaction in situ for potent antimicrobial efficacy and wound protection. This strategy of “two birds with one stone” provides a convenient method for the application of supramolecular nanomaterial in the field of biomedicine.

中文翻译：

葡萄糖激活的纳米限制超分子级联原位反应用于糖尿病伤口愈合

超分子纳米功能材料由于其在生物医学方面的优势，越来越受到科研人员的关注。在此，我们通过壳聚糖、磺丁基醚-β-环糊精、亚铁离子和葡萄糖氧化酶等多个非共价键的协同作用构建了一个纳米超分子级联反应器。在葡萄糖的活化下，纳米限域超分子级联反应过程中产生的羟基自由基能够引发乙烯基单体的自由基聚合过程，形成水凝胶网络结构，同时抑制耐药细菌感染。糖尿病伤口实验的结果证实了原位葡萄糖激活纳米限制超分子级联反应的能力具有强大的抗菌功效和伤口保护作用。这种“一石二鸟”的策略为超分子纳米材料在生物医学领域的应用提供了便捷的途径。

更新日期：2022-06-13

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