Functional analysis reveals ionotropic GABA receptor subunit RDL is a target site of ivermectin and fluralaner in the yellow fever mosquito, Aedes aegypti,Pest Management Science

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Functional analysis reveals ionotropic GABA receptor subunit RDL is a target site of ivermectin and fluralaner in the yellow fever mosquito, Aedes aegypti
Pest Management Science ( IF 3.8 ) Pub Date : 2022-06-12 , DOI: 10.1002/ps.7035
Qiuhui Wang _{1,

2} , Haocheng Wang _{1,

2} , Yingxin Zhang ₁ , Jing Chen _{1,

2} , Archana Upadhyay _{1,

2} , Biswajit Bhowmick _{1,

2} , Jiayu Hang ₁ , Shaoying Wu ₃ , Chenghong Liao _{1,

2} , Qian Han _{1,

2}

Affiliation

Ionotropic γ-aminobutyric acid (iGABA) receptors are involved in various physiological activities in insects, including sleep, olfactory memory, movement, and resistance to viruses. Ivermectin and fluralaner can disturb the insect nervous system by binding to iGABA receptors, and are therefore an effective means for controlling insect pests. However, the molecular mechanisms underlying the insecticidal effect of both the compounds on Aedes. aegypti remain unexplored.

中文翻译：

功能分析表明，离子型 GABA 受体亚基 RDL 是黄热病蚊子、埃及伊蚊中伊维菌素和氟拉那的靶位点

离子型 γ-氨基丁酸 (iGABA) 受体参与昆虫的各种生理活动，包括睡眠、嗅觉记忆、运动和对病毒的抵抗力。伊维菌素和氟拉那可通过与iGABA受体结合而扰乱昆虫神经系统，是防治害虫的有效手段。然而，这两种化合物对伊蚊的杀虫作用的分子机制。埃及尚未开发。

更新日期：2022-06-12

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