Reductions in hippocampal volume (HV) have been associated with both prolonged exposure to stress and psychotic illness. This study sought to determine whether higher levels of neighborhood poverty would be associated with reduced HV among individuals at clinical high-risk for psychosis (CHR-P), and whether social engagement would moderate this association. This cross-sectional study included a sample of participants (N  =  174, age-range = 12-33 years, 35.1% female) recruited for the second phase of the North American Prodrome Longitudinal Study. Generalized linear mixed models tested the association between neighborhood poverty and bilateral HV, as well as the moderating role of social engagement on this association. Higher levels of neighborhood poverty were associated with reduced left (β  =  -0.180, P  =  .016) and right HV (β  =  -0.185, P  =  .016). Social engagement significantly moderated the relation between neighborhood poverty and bilateral HV. In participants with lower levels of social engagement (n  =  77), neighborhood poverty was associated with reduced left (β  =  -0.266, P  =  .006) and right HV (β = -0.316, P  = .002). Among participants with higher levels of social engagement (n = 97), neighborhood poverty was not significantly associated with left (β  =  -0.010, P  =  .932) or right HV (β  =  0.087, P  =  .473). In this study, social engagement moderated the inverse relation between neighborhood poverty and HV. These findings demonstrate the importance of including broader environmental influences and indices of social engagement when conceptualizing adversity and potential interventions for individuals at CHR-P.

中文翻译：

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邻里贫困与临床精神病高危个体海马体积之间的关联：社会参与的调节作用。

海马体积（HV）的减少与长期承受压力和精神疾病有关。本研究旨在确定较高的社区贫困程度是否与精神病临床高危人群 (CHR-P) 的 HV 降低有关，以及社会参与是否会调节这种关联。这项横断面研究包括为北美前驱症状纵向研究第二阶段招募的参与者样本（N = 174，年龄范围 = 12-33 岁，35.1% 女性）。广义线性混合模型测试了邻里贫困与双边高压之间的关联，以及社会参与对此关联的调节作用。较高水平的邻里贫困与左侧 HV (β = -0.180, P = .016) 和右侧 HV (β = -0.185, P = .016) 的降低有关。社会参与显着调节了邻里贫困与双边高压之间的关系。在社会参与水平较低的参与者 (n = 77) 中，邻里贫困与左 HV (β = -0.266，P = .006) 和右 HV (β = -0.316，P = .002) 的降低相关。在社会参与水平较高的参与者中 (n = 97)，邻里贫困与左 HV (β = -0.010，P = .932) 或右 HV (β = 0.087，P = .473) 没有显着相关。在这项研究中，社会参与调节了社区贫困与高压之间的反比关系。这些发现表明，在构思 CHR-P 个人的逆境和潜在干预措施时，包括更广泛的环境影响和社会参与指数的重要性。