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Development of an anthropomorphic phantom based on 3D printing for assessment of dose delivered to the eye and adjacent tissues
Radiation Physics and Chemistry ( IF 2.8 ) Pub Date : 2022-06-11 , DOI: 10.1016/j.radphyschem.2022.110292
Dirceu D. Pereira , Simone C. Cardoso , Delano V.S. Batista , Felipe M.L. de Souza , Juan V.M. de Sousa , Odair D. Gonçalves , Luiz A.R. da Rosa

The objective of this work was to build slices containing the eye region using 3D printing, to be inserted in an anthropomorphic phantom, allowing to perform the dosimetry of organs associated with the eye. The slices were built using PLA 3D printing for soft tissue and a mixture of calcium sulfate dihydrate and sodium chloride for the cranial bones. Different mixtures were tested to simulate bone tissue. The phantom containing LiF TLD 100 micro cubes in proper positions was validated for the determination of doses to the eye and to organs at risk. For the mass attenuation coefficient and energies between 1 and 10 MeV, the percentage differences between the data for the three mixtures and that for cortical bone was less than 2%. When analyzing the electronic density, all mixtures differed by more than 10% in relation to bone tissue. The use of Hounsfield Units as the only parameter to characterize the tissue equivalence is not recommended. The results showed that the mixture with 46% calcium sulfate is the closest to the cortical bone of the ATOM® phantom. The printed phantom containing TLDs was used to measure the doses in deeper regions of ocular system as the optical nerves and fundus of the eye. The results differed about 2% from the planned ones. For more superficial regions (like the lens), the use of dose compensators should be used to provide electronic equilibrium conditions. Results showed the feasibility of using the three-dimensional printed phantom developed.



中文翻译:

开发基于 3D 打印的拟人模型,用于评估传递到眼睛和邻近组织的剂量

这项工作的目的是使用 3D 打印构建包含眼睛区域的切片,将其插入拟人模型中,从而对与眼睛相关的器官进行剂量测定。这些切片是使用 PLA 3D 打印制作软组织,使用二水硫酸钙和氯化钠的混合物制作颅骨。测试了不同的混合物以模拟骨组织。验证了在适当位置包含 LiF TLD 100 微型立方体的体模以确定眼睛和危险器官的剂量。对于 1 到 10 MeV 之间的质量衰减系数和能量,三种混合物的数据与皮质骨的数据之间的百分比差异小于 2%。在分析电子密度时,所有混合物与骨组织的差异超过 10%。不推荐使用 Hounsfield 单位作为表征组织等效性的唯一参数。结果表明,含有 46% 硫酸钙的混合物最接近 ATOM® 模型的皮质骨。打印的包含 TLD 的模型用于测量眼系统较深区域的剂量,如视神经和眼底。结果与计划的结果相差约 2%。对于更浅的区域(如晶状体),应使用剂量补偿器来提供电子平衡条件。结果表明使用所开发的三维打印模型的可行性。结果表明,含有 46% 硫酸钙的混合物最接近 ATOM® 模型的皮质骨。打印的包含 TLD 的模型用于测量眼系统较深区域的剂量,如视神经和眼底。结果与计划的结果相差约 2%。对于更浅的区域(如晶状体),应使用剂量补偿器来提供电子平衡条件。结果表明使用所开发的三维打印模型的可行性。结果表明,含有 46% 硫酸钙的混合物最接近 ATOM® 模型的皮质骨。打印的包含 TLD 的模型用于测量眼系统较深区域的剂量,如视神经和眼底。结果与计划的结果相差约 2%。对于更浅的区域(如晶状体),应使用剂量补偿器来提供电子平衡条件。结果表明使用所开发的三维打印模型的可行性。应使用剂量补偿器来提供电子平衡条件。结果表明使用所开发的三维打印模型的可行性。应使用剂量补偿器来提供电子平衡条件。结果表明使用所开发的三维打印模型的可行性。

更新日期:2022-06-11
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