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Blood donation improves skin aging through the reduction of iron deposits and the increase of TGF-β1 in elderly skin
Mechanisms of Ageing and Development ( IF 5.3 ) Pub Date : 2022-06-10 , DOI: 10.1016/j.mad.2022.111687
Junhao Liu 1 , Tingting Chen 1 , Yang Zhao 1 , Zhao Ding 1 , Wenhao Ge 1 , Jianfa Zhang 1
Affiliation  

Skin aging is characterized by a wide range of physiological and structural changes, including wrinkling, dyschromia, and roughness, as well as the reduction of dermal thickness and collagen content. Here, we showed that blood donation increased dermal thickness and collagen content and decreased the number of senescent cells in old mice. Transcriptomic and metabolomic studies revealed blood donation significantly altered aging-related pathways in the skin of old mice. Molecular genes analysis indicated blood donation decreased the expression of genes associated with inflammation such as Fols1, Cox-2, and IL-1β, and increased the expression of collagen-associated genes including TGF-β1, TGF-β2, and Col3a1. The improvement of skin aging by blood donation was associated with the reduction of iron deposits and the increase of TGF-β1 in elderly skin. Our results suggested that appropriate blood donation could promote collagen re-synthesis and improve skin aging.



中文翻译:

献血通过减少老年人皮肤中的铁沉积和增加 TGF-β1 来改善皮肤老化

皮肤老化的特点是广泛的生理和结构变化,包括皱纹、色素异常和粗糙,以及真皮厚度和胶原蛋白含量的减少。在这里,我们发现献血增加了老年小鼠的真皮厚度和胶原蛋白含量,并减少了衰老细胞的数量。转录组学和代谢组学研究表明,献血显着改变了老年小鼠皮肤中与衰老相关的通路。分子基因分析表明,献血降低了炎症相关基因如Fols1Cox-2IL-1β的表达,增加了胶原相关基因包括TGF-β1TGF-β2科尔3a1。献血对皮肤老化的改善与老年人皮肤中铁沉积的减少和 TGF-β1 的增加有关。我们的研究结果表明,适当的献血可以促进胶原蛋白的重新合成并改善皮肤老化。

更新日期:2022-06-10
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