Cardiogenic shock is a clinical syndrome of impaired tissue perfusion caused by primary cardiac dysfunction and inadequate cardiac output. It represents one of the most lethal clinical conditions in intensive care medicine with mortality >40%. Management of different clinical presentations of cardiogenic shock includes guidance of cardiac preload, afterload, heart rate and contractility by differential pharmacological modulation of volume, systemic and pulmonary vascular resistance and cardiac output besides reversing the triggering cause. Data from large registries and randomized controlled trials on optimal diagnostic guidance as well as choice of pharmacological agents has accrued significantly in recent years. This state-of-the-art review summarizes the basic concepts of cardiogenic shock, the diagnostic work-up and currently available evidence and guideline recommendations on pharmacological treatment of cardiogenic shock.

心源性休克是由原发性心功能不全和心输出量不足引起的组织灌注受损的临床综合征。它是重症监护医学中最致命的临床病症之一，死亡率 >40%。心源性休克不同临床表现的管理包括通过不同的药理学调节容积、全身和肺血管阻力以及心输出量来指导心脏前负荷、后负荷、心率和收缩力，以及逆转触发原因。近年来，来自大型注册中心和随机对照试验的关于最佳诊断指导以及药物选择的数据显着增加。这篇最先进的综述总结了心源性休克的基本概念，