Background

Multiorgan dysfunction, especially sepsis-related multiorgan damage, remains a major cause of high mortality in the late stages of infection and a great clinical challenge. In recent years, natural drugs have received widespread attention because of their low cost, wide sources, high efficacy, low toxicity, and limited side effects. Lycorine, a natural compound extracted from Amaryllidaceae, exhibits multiple pharmacological activities, including in the regulation of autophagy and the induction of cancer cell apoptosis, and has anti-inflammatory, antifungal, antiviral, antimalarial, and antitumor activities. However, studies on lycorine have mainly focused on its antitumor properties, and research on its use for organ protection, especially in sepsis-related organ injury, is relatively limited.

Purpose

To review and discuss the effects and mechanisms of lycorine in the treatment of multi-organ dysfunction, especially sepsis.

Methods

Literature searches in electronic databases, such as Web of Science, Science Direct, PubMed, Google Scholar, and Scopus, were performed using 'Lycorine', 'Amaryllidaceae', 'Pharmacology', 'Pharmacokinetics', 'Anti-inflammation', 'Autophagy', 'Apoptosis', 'Anti-microbial and anti-parasitic', 'Antitumor', 'Organ protection', and 'Sepsis' as keywords, the correlated literature was extracted and conducted from the databases mentioned above.

Results

By summarizing the progress made in existing research, we found that the general effects of lycorine involve the regulation of autophagy and the induction of cancer cell apoptosis, and anti-inflammatory, antifungal, antiviral, antimalarial, and antitumor effects; through these pathways, the compound can ameliorate organ damage. In addition, lycorine was found to have an important effect on organ damage in sepsis.

Conclusion

Lycorine is a promising natural organ protective agent. This review will provide a new theoretical basis for the treatment of organ protection, especially in sepsis.

中文翻译：

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石蒜碱和器官保护：回顾其潜在作用和分子机制

背景

多器官功能障碍，尤其是与脓毒症相关的多器官损伤，仍然是感染晚期高死亡率的主要原因，也是一个巨大的临床挑战。近年来，天然药物以其成本低、来源广、疗效高、毒性低、副作用少等优点受到广泛关注。石蒜碱是一种从石蒜科中提取的天然化合物，具有多种药理活性，包括调节自噬和诱导癌细胞凋亡，并具有抗炎、抗真菌、抗病毒、抗疟疾和抗肿瘤活性。然而，关于石蒜碱的研究主要集中在其抗肿瘤特性上，对其用于器官保护，特别是在败血症相关器官损伤方面的研究相对有限。

目的

回顾和讨论石蒜碱治疗多器官功能障碍，尤其是脓毒症的作用和机制。

方法

使用“Lycorine”、“Amaryllidaceae”、“Pharmacology”、“Pharmacokinetics”、“Anti-inflammation”、“Autophagy”在电子数据库（如 Web of Science、Science Direct、PubMed、Google Scholar 和 Scopus）中进行文献搜索'、'细胞凋亡'、'抗微生物和抗寄生虫'、'抗肿瘤'、'器官保护'和'败血症'为关键词，从上述数据库中提取并进行相关文献。

结果

通过总结现有研究取得的进展，我们发现石蒜碱的一般作用包括调节自噬和诱导癌细胞凋亡，以及抗炎、抗真菌、抗病毒、抗疟和抗肿瘤作用；通过这些途径，该化合物可以改善器官损伤。此外，发现石蒜碱对脓毒症的器官损伤有重要作用。

结论

石蒜碱是一种很有前途的天然器官保护剂。本综述将为器官保护，特别是脓毒症的治疗提供新的理论依据。