Senescence is a specialized form of cell cycle arrest induced in response to damage and stress. In certain settings, senescent cells can promote their own removal by recruitment of the immune system, a process that is thought to decline in efficiency with age. In this issue of Genes & Development, Yin et al. (pp. 533–549) discover a surprising cross-talk where senescent cells instruct endothelial cells to help organize the clearance of the senescent population. This uncovers yet another layer of complexity in senescent cell biology, with implications for cancer treatment and aging.

中文翻译：

---

内皮细胞促进衰老监测

衰老是响应损伤和压力而诱导的一种特殊形式的细胞周期停滞。在某些情况下，衰老细胞可以通过招募免疫系统来促进自身的清除，这一过程被认为会随着年龄的增长而降低效率。在本期《基因与发展》中，尹等人。(pp. 533–549) 发现了一个令人惊讶的串扰，其中衰老细胞指示内皮细胞帮助组织清除衰老群体。这揭示了衰老细胞生物学的另一层复杂性，对癌症治疗和衰老有影响。