Background: Chemotherapy for stomach cancer often includes several side effects. The primary reasons for the failure of such treatment approaches are low drug concentrations in target tissues and a short stomach residence time. Objective: Gastroretentive controlled drug delivery systems improves the therapeutic performance of chemotherapeutic drugs following oral administration because of the longer gastric retention time. The goal of this study was to find suitable gastroretentive formulations that might be used for the localized treatment of stomach cancer. Methods: The purpose of this study is to summarize current advances in gastro-retentive drug administration for oral chemotherapy, with a focus on floating, mucoadhesive, and swellable systems. This article also discusses the potentials and limitations of existing gastroretentive drug delivery systems used in cancer chemotherapy. Results: Due to increased stomach retention and modified drug release properties, gastroretentive controlled drug delivery systems improve the therapeutic performance of anti-cancer drugs used to treat stomach cancer. Conclusion: Gastroretentive drug delivery systems appear to be a promising carrier for localized chemotherapy with smaller doses and better patient compliance. However, selection of drug candidates, drugfood interactions and chemotherapy-induced gastric discomfort remain the key characteristics that must be addressed to improve treatment outcomes.

中文翻译：

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癌症化疗中的胃滞留给药系统

背景：胃癌的化疗通常包括多种副作用。这种治疗方法失败的主要原因是靶组织中的药物浓度低和胃停留时间短。目的：由于胃滞留时间较长，胃滞留控制给药系统可改善口服化疗药物的治疗效果。本研究的目的是寻找可用于胃癌局部治疗的合适胃滞留制剂。方法：本研究的目的是总结口服化疗胃滞留药物的当前进展，重点是漂浮、粘膜粘附和可膨胀系统。本文还讨论了用于癌症化疗的现有胃滞留药物输送系统的潜力和局限性。结果：由于增加了胃滞留和改进的药物释放特性，胃滞留控制药物递送系统改善了用于治疗胃癌的抗癌药物的治疗性能。结论：胃滞留药物递送系统似乎是一种有前途的局部化疗载体，具有更小的剂量和更好的患者依从性。然而，候选药物的选择、药物与食物的相互作用和化疗引起的胃部不适仍然是改善治疗结果必须解决的关键特征。胃滞留控制药物递送系统改善了用于治疗胃癌的抗癌药物的治疗性能。结论：胃滞留药物递送系统似乎是一种有前途的局部化疗载体，具有更小的剂量和更好的患者依从性。然而，候选药物的选择、药物与食物的相互作用和化疗引起的胃部不适仍然是改善治疗结果必须解决的关键特征。胃滞留控制药物递送系统改善了用于治疗胃癌的抗癌药物的治疗性能。结论：胃滞留药物递送系统似乎是一种有前途的局部化疗载体，具有更小的剂量和更好的患者依从性。然而，候选药物的选择、药物与食物的相互作用和化疗引起的胃部不适仍然是改善治疗结果必须解决的关键特征。