Synthesis of Saturated N-Heterocycles via a Catalytic Hydrogenation Cascade,Advanced Synthesis & Catalysis

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Synthesis of Saturated N-Heterocycles via a Catalytic Hydrogenation Cascade
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2022-06-08 , DOI: 10.1002/adsc.202200601
Tobias Wagener ₁ , Marco Pierau ₁ , Arne Heusler ₁ , Frank Glorius ₁

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Saturated N-heterocycles are prominent motifs found in various natural products and pharmaceuticals. Despite the increasing interest in this class of compounds, the synthesis of saturated bicyclic azacycles requires tedious multi-step syntheses. Herein, we present a one-pot protocol for the synthesis of octahydroindoles, decahydroquinolines, and octahydroindolizines through a cascade reaction.

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