当前位置: X-MOL 学术Adv. Synth. Catal. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Synthesis of Saturated N-Heterocycles via a Catalytic Hydrogenation Cascade
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2022-06-08 , DOI: 10.1002/adsc.202200601
Tobias Wagener 1 , Marco Pierau 1 , Arne Heusler 1 , Frank Glorius 1
Affiliation  

Saturated N-heterocycles are prominent motifs found in various natural products and pharmaceuticals. Despite the increasing interest in this class of compounds, the synthesis of saturated bicyclic azacycles requires tedious multi-step syntheses. Herein, we present a one-pot protocol for the synthesis of octahydroindoles, decahydroquinolines, and octahydroindolizines through a cascade reaction.

中文翻译:

通过催化加氢级联合成饱和氮杂环

饱和 N-杂环是各种天然产物和药物中发现的突出基序。尽管人们对这类化合物越来越感兴趣,但饱和双环氮杂环的合成需要繁琐的多步骤合成。在此,我们提出了一种通过级联反应合成八氢吲哚、十氢喹啉和八氢吲嗪的一锅法。
更新日期:2022-06-08
down
wechat
bug