A simple protocol for the sulfur-promoted conversion of aromatic aldehydes to aromatic nitriles has been developed. This strategy enables the one-pot conversion of inexpensive and readily available aromatic aldehydes into highly valuable aromatic nitriles using a cheap inorganic ammonium salt as the nitrogen source in the absence of metals. Significantly, a broad scope of substrates was explored using this strategy, and various groups, including alkyl, alkoxyl, alkylthiol, hydroxyl, amino, aryl, alkenyl, cyano, carboxyl, and borate ester groups were tolerated, and good to excellent yields were achieved in most cases. Additionally, polycyclic aromatic aldehydes and heteroaromatic aldehydes also could be converted to the corre-sponding nitriles with satisfactory yields. This method can be utilized as a powerful tool for the cyanation of complex molecules.

开发了一种用于将硫促进的芳香醛转化为芳香腈的简单方案。该策略能够在不存在金属的情况下，使用廉价的无机铵盐作为氮源，将廉价且容易获得的芳香醛一锅法转化为高价值的芳香腈。值得注意的是，使用该策略探索了广泛的底物范围，并且可以耐受各种基团，包括烷基、烷氧基、烷基硫醇、羟基、氨基、芳基、烯基、氰基、羧基和硼酸酯基团，并实现了良好到极好的收率在多数情况下。此外，多环芳醛和杂芳醛也可以转化为相应的腈，收率令人满意。