The simultaneous binding/dissociation of multiple bonds in a one-pot manner by multicomponent reactions provide an important approach for developing novel and sustainable pathway in the drug discovery process. Herein we develop an electrocatalytic three-component reaction to construct multifunctional and valuable isothiourea compounds, which uses thiols, isocyanides and amines as substrates. Compared with the previous work, the organic electrosynthesis technique can avoid the requirement of heavy metal catalysts and stoichiometric oxidants. In addition, using thiol as a substrate to participate in the three-component reaction broadens the source of sulfur, which can also construct more abundant isothiourea derivatives.

通过多组分反应以一锅法同时结合/解离多个键，为在药物发现过程中开发新的和可持续的途径提供了重要途径。在此，我们开发了一种电催化三组分反应，以构建多功能且有价值的异硫脲化合物，该化合物使用硫醇、异氰化物和胺作为底物。与之前的工作相比，有机电合成技术可以避免重金属催化剂和化学计量氧化剂的需求。此外，以硫醇为底物参与三元反应拓宽了硫的来源，也可以构建更丰富的异硫脲衍生物。