Abstract The aim of the present study was to formulate a fluconazole cream for the treatment of Candida albicans. The optimized cream formulation was prepared using stearic acid, oleic acid, beeswax and borax. The uniform distribution of the active ingredient fluconazole could be confirmed in all formulated creams. The FC-C-C formulation showed satisfactory spreadability and extrudability. FC-C-C delivered (95.07 ± 15.85)% in only 36 h, and the formulation released the drug by an anomalous diffusion mechanism. The viscosity of FC-C-C was found to be (63.20 ± 0.83) cP. The antifungal study and animal studies confirmed that the prepared formulation is non-irritant and has an enhanced antifungal activity that reduces the side effects of fluconazole. The studies confirm that the prepared formulation may be useful for the treatment of Candida albicans.

中文翻译：

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开发用于治疗白色念珠菌的增强抗真菌活性和减少氟康唑副作用的乳膏

摘要 本研究的目的是研制一种治疗白色念珠菌的氟康唑乳膏。使用硬脂酸、油酸、蜂蜡和硼砂制备优化的奶油配方。活性成分氟康唑的均匀分布可以在所有配制的乳膏中得到证实。FC-CC 配方表现出令人满意的铺展性和挤出性。FC-CC 仅在 36 小时内释放 (95.07 ± 15.85)%，并且制剂通过异常扩散机制释放药物。发现 FC-CC 的粘度为 (63.20 ± 0.83) cP。抗真菌研究和动物研究证实，制备的制剂无刺激性，抗真菌活性增强，可减少氟康唑的副作用。