Hydration and pH monitoring provide clinically relevant information of preventative medicine, disease diagnostics, and patient care is of great importance. However, traditional materials have limited in flexible sensors due to the long-term on-skin health monitoring, which requires high flexibility, biocompatibility, biodegradability, comfortableness, and air permeability. In this paper, micro hydration and pH sensors were integrated on a composite silk fibroin (C–SF) film for real-time health monitoring. The excellent biocompatibility and flexibility of the C–SF film allow long-term non-allergenic and comfortable with skin contact. Moreover, the flexible hydration sensors had high selectivity and sensitivity, which was sensitive to hydration change in skin and insensitive to humidity change. Within the range of hydration from 25 to 65%, the change of the capacitance has a certain linear relationship C = 0.0121 M (%) + 2.9477 where, C is the capacitance value of the hydration sensor, M is the hydration of the artificial skin. In addition, pH response in different phosphate buffered saline (PBS) linearly is increased from 4 to 9. The open-circuit voltage (OCV) is decreased from  − 0.023 to  − 0.136 mV. Wearable multifunctional sensors potentially allow ‘fit for purpose’ biomedical applications, such as long-term health monitoring and disease alerts.

中文翻译：

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基于蛋白质膜的可穿戴水化和pH传感器用于医疗保健监测

水合作用和 pH 值监测提供预防医学、疾病诊断和患者护理的临床相关信息非常重要。然而，传统材料由于长期在皮肤上的健康监测，在柔性传感器方面受到限制，这需要高度的柔韧性、生物相容性、生物降解性、舒适性和透气性。在本文中，微水化和 pH 传感器集成在复合丝素蛋白 (C-SF) 薄膜上，用于实时健康监测。C-SF 薄膜优异的生物相容性和柔韧性可实现长期无过敏性和舒适的皮肤接触。此外，柔性水化传感器具有较高的选择性和灵敏度，对皮肤水化变化敏感，对湿度变化不敏感。在 25% 到 65% 的水化范围内，电容的变化具有一定的线性关系 C = 0.0121 M (%) + 2.9477 其中，C 为水化传感器的电容值，M 为人造皮肤的水化度。此外，不同磷酸盐缓冲盐水 (PBS) 中的 pH 响应从 4 线性增加到 9。开路电压 (OCV) 从 - 0.023 降低到 - 0.136 mV。可穿戴多功能传感器可能允许“适合目的”的生物医学应用，例如长期健康监测和疾病警报。开路电压 (OCV) 从 - 0.023 降至 - 0.136 mV。可穿戴多功能传感器可能允许“适合目的”的生物医学应用，例如长期健康监测和疾病警报。开路电压 (OCV) 从 - 0.023 降至 - 0.136 mV。可穿戴多功能传感器可能允许“适合目的”的生物医学应用，例如长期健康监测和疾病警报。