Abstract Hydrogels are promising drug delivery systems attributable to their unique characteristics such as high hydrophilicity, controllability, biocompatibility, and facile production routines. The aim of this research was the preparation of sodium alginate/acrylic acid (AAc) composite hydrogels conjugated to silver nanoparticles to deliver the cephalexin as a model antibiotic compound. The reduction of silver ions into silver nanoparticles as well as the stabilization of created nanoparticles ensued simultaneously with hydrogel backbone formulation during microwave irradiation and monomer cross-linking processes. The impact of AAc and silver ion concentrations and the radiation time of microwave were then investigated on the main characteristics of hydrogels. The results indicated that the hydrogels’ characteristics could be significantly predicted by studying all independent parameters through various second-order polynomial models. The multiple optimization analysis suggested that the prepared hydrogels using 7.8 g AAc and 1.5 g silver nitrate and 1 min microwave radiation could give the best hydrogels with the highest swelling degree, gel fraction, cephalexin absorption, and antibacterial activity. The morphology and either absorption or release kinetics of cephalexin by the optimum prepared hydrogels were also investigated. No significant differences between the experimental and predicted data confirmed the suitability of the suggested models.

中文翻译：

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海藻酸钠/丙烯酸复合水凝胶与银纳米粒子共轭作为抗生素递送系统的制备和表征

摘要 水凝胶由于其独特的特性，如高亲水性、可控性、生物相容性和简便的生产程序，是很有前途的药物输送系统。本研究的目的是制备与银纳米粒子结合的海藻酸钠/丙烯酸 (AAc) 复合水凝胶，以提供头孢氨苄作为模型抗生素化合物。在微波辐射和单体交联过程中，银离子还原成银纳米颗粒以及产生的纳米颗粒的稳定性与水凝胶骨架配方同时进行。然后研究了AAc和银离子浓度以及微波辐射时间对水凝胶主要特性的影响。结果表明，通过各种二阶多项式模型研究所有独立参数，可以显着预测水凝胶的特性。多重优化分析表明，使用 7.8 g AAc 和 1.5 g 硝酸银和 1 min 微波辐射制备的水凝胶可以得到最好的水凝胶，具有最高的溶胀度、凝胶分数、头孢氨苄吸收和抗菌活性。还研究了最佳制备的水凝胶对头孢氨苄的形态和吸收或释放动力学。实验数据和预测数据之间没有显着差异证实了建议模型的适用性。多重优化分析表明，使用 7.8 g AAc 和 1.5 g 硝酸银和 1 min 微波辐射制备的水凝胶可以得到最好的水凝胶，具有最高的溶胀度、凝胶分数、头孢氨苄吸收和抗菌活性。还研究了最佳制备的水凝胶对头孢氨苄的形态和吸收或释放动力学。实验数据和预测数据之间没有显着差异证实了建议模型的适用性。多重优化分析表明，使用 7.8 g AAc 和 1.5 g 硝酸银和 1 min 微波辐射制备的水凝胶可以得到最好的水凝胶，具有最高的溶胀度、凝胶分数、头孢氨苄吸收和抗菌活性。还研究了最佳制备的水凝胶对头孢氨苄的形态和吸收或释放动力学。实验数据和预测数据之间没有显着差异证实了建议模型的适用性。还研究了最佳制备的水凝胶对头孢氨苄的形态和吸收或释放动力学。实验数据和预测数据之间没有显着差异证实了建议模型的适用性。还研究了最佳制备的水凝胶对头孢氨苄的形态和吸收或释放动力学。实验数据和预测数据之间没有显着差异证实了建议模型的适用性。