OBJECTIVE Hematopoietic stem cell transplantation (HSCT) is an effective treatment for pediatric high-risk acute lymphoblastic leukemia (ALL) survivors. Still, both the disease and treatment often impair cognitive and motor functions, and HSCT is a risk factor for long-term deficits. The study aimed at investigating the effect of HSCT on cognitive, motor, and visual-motor functions. Two groups were enrolled: The first group received HSCT treatment, and the second group did not. METHOD Sixty-five ALL survivors participated in the study (ages: 7-17). Twenty-one of participants who underwent HSCT comprised the first group. We implemented tests from Cambridge Neuropsychological Test Automated Battery, Wechsler Intelligence Scale for Children, and Test of Memory and Learning to estimate cognitive functions, Bruininks-Oseretsky Test of Motor Proficiency to estimate motor functions, and Beery-Buktenica Developmental Test to estimate visual perceptual and visual motor functions. As independent variables for analysis we chose group (HSCT+/-), age at diagnosis, and current age. RESULTS MANCOVA test demonstrated significant effect of current age on cognitive functions (partial η2 = 0.55) and significant effect of HSCT treatment on motor functions (partial η2 = 0.19). Current age also had moderate effect on visual-motor functions (partial η2 = 0.11). Significant differences were found in most cognitive, motor, and visual-motor tests' results between the two groups, with HSCT+ group demonstrating poorer performance. CONCLUSIONS This study has several limitations, including small sample size, potentially mismatched groups, imbalanced gender ratio. Still, the findings underline the importance of considering late effects of HSCT, and age when designing rehabilitation programs.

中文翻译：

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有和没有异基因造血干细胞移植的小儿急性淋巴细胞白血病幸存者的认知、运动和视觉运动功能的比较分析。

目的造血干细胞移植（HSCT）是治疗儿科高危急性淋巴细胞白血病（ALL）幸存者的有效方法。尽管如此，疾病和治疗通常都会损害认知和运动功能，并且 HSCT 是长期缺陷的危险因素。该研究旨在调查 HSCT 对认知、运动和视觉运动功能的影响。入组两组：第一组接受 HSCT 治疗，第二组不接受。方法 65 名所有幸存者参加了研究（年龄：7-17）。21 名接受 HSCT 的参与者构成第一组。我们实施了剑桥神经心理学测试自动电池、韦氏儿童智力量表以及记忆和学习测试来估计认知功能，Bruininks-Oseretsky 运动能力测试估计运动功能，Beery-Buktenica 发育测试估计视觉感知和视觉运动功能。作为分析的自变量，我们选择了组（HSCT+/-）、诊断年龄和当前年龄。结果 MANCOVA 测试表明当前年龄对认知功能的显着影响（部分 η2 = 0.55）和 HSCT 治疗对运动功能的显着影响（部分 η2 = 0.19）。当前年龄对视觉运动功能也有中等影响（部分 η2 = 0.11）。两组之间的大多数认知、运动和视觉运动测试结果存在显着差异，HSCT+组表现较差。结论 本研究存在一些局限性，包括样本量小、可能不匹配的组、不平衡的性别比例。