Application of Analytical Tools and Techniques for Estimation of a Proton Pump Inhibitor (Esomeprazole Magnesium Trihydrate): A Comprehensive Review,Current Pharmaceutical Analysis

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Application of Analytical Tools and Techniques for Estimation of a Proton Pump Inhibitor (Esomeprazole Magnesium Trihydrate): A Comprehensive Review
Current Pharmaceutical Analysis ( IF 0.7 ) Pub Date : 2022-04-27 , DOI: 10.2174/1573412918666220426110831
Sanat Kumar Dash ₁ , Sasmita Kumari Acharjya ₁ , Atyurmila Chakraborty ₁ , Mitali Sahoo ₁ , Satyanarayan Tripathy ₁ , Bimala Tripathy ₁ , Ramanath Deo ₁

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: The application of various sophisticated analytical tools and techniques is essential for estimating an active pharmaceutical ingredient present in either biofluids or pharmaceutical dosage forms. Reporting the multiple analytical methods used to quantify esomeprazole magnesium trihydrate, a proton pump inhibitor, is the ultimate goal of this review article. This article deals with a detailed discussion of different reported analytical procedures along with their pros and cons and their relevant criteria for quantifying the drug. Various analytical techniques like UV-Visible spectrophotometry, HPLC, HPTLC, hyphenated techniques, etc., are developed to assess the esomeprazole magnesium trihydrate in bulk materials, different pharmaceutical formulations, and biological matrices. Literature survey confirmed that the hyphenated techniques and chromatographic techniques are the best tools for biological matrices. Spectroscopic methods like UV and visible techniques are widely used for pharmaceutical matrices. All of the reported methods are accurate, precise, costeffective, and sensitive.

中文翻译：

分析工具和技术在质子泵抑制剂（埃索美拉唑三水合物）评估中的应用：综合回顾

：应用各种复杂的分析工具和技术对于估计生物流体或药物剂型中存在的活性药物成分至关重要。报告用于定量埃索美拉唑镁三水合物（一种质子泵抑制剂）的多种分析方法是这篇综述文章的最终目标。本文详细讨论了不同报告的分析程序及其优缺点及其量化药物的相关标准。开发了各种分析技术，如紫外-可见分光光度法、HPLC、HPTLC、联用技术等，以评估散装材料、不同药物制剂和生物基质中的埃索美拉唑镁三水合物。文献调查证实，联用技术和色谱技术是生物基质的最佳工具。紫外和可见光技术等光谱方法广泛用于药物基质。所有报告的方法都是准确、精确、经济高效且灵敏的。

更新日期：2022-04-27

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