Antibiotic polymer conjugates (APCs) are an essential part of polymer therapeutics. These conjugates have been used as an appealing platform for drug delivery. As a delivery vector, the administration route severely impacts the accessibility of antibiotics to their respective target site and therapeutic index. Furthermore, the physicochemical and biological properties of conjugates also correlate distinctly with the route of administration. The APCs delivery methods that have been disclosed so far suffer from significant constraints due to poor technology and constrained administration routes (mainly injections). Leading to promising directions, which include the development of specific characteristics for each polymer carrier, application of novel biodegradable polymers, expansion of traditional drug administration routes through the development of emerging routes, and the development of a rational and systematic methodology for designing administration routes are yet to be explored widely. This review focuses primarily on recent improvements in various routes of administration (dental, topical, and ocular) employing APCs. The mechanism of action, as well as other perspectives, have also been discussed. Moreover, this innovative technology provides a fresh perspective on pharmaceutical science research and offers unique and potential pathways for designing desired APCs.

中文翻译：

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涉及抗生素聚合物偶联物治疗各种疾病的新疗法：综述

抗生素聚合物偶联物 (APC) 是聚合物治疗的重要组成部分。这些缀合物已被用作药物递送的有吸引力的平台。作为递送载体，给药途径严重影响抗生素对其各自靶位点和治疗指数的可及性。此外，缀合物的物理化学和生物学特性也与给药途径明显相关。由于技术落后和给药途径（主要是注射）受限，迄今为止已公开的 APC 递送方法受到重大限制。导致有前景的方向，包括开发每种聚合物载体的特定特性，新型可生物降解聚合物的应用，通过开发新兴途径来扩展传统的给药途径，以及开发合理和系统的给药途径设计方法尚待广泛探索。这篇综述主要关注最近在使用 APC 的各种给药途径（牙科、局部和眼部）方面的改进。还讨论了作用机制以及其他观点。此外，这项创新技术为药物科学研究提供了全新的视角，并为设计所需的 APC 提供了独特和潜在的途径。局部和眼部）使用 APC。还讨论了作用机制以及其他观点。此外，这项创新技术为药物科学研究提供了全新的视角，并为设计所需的 APC 提供了独特和潜在的途径。局部和眼部）使用 APC。还讨论了作用机制以及其他观点。此外，这项创新技术为药物科学研究提供了全新的视角，并为设计所需的 APC 提供了独特和潜在的途径。