To evaluate the clinical outcomes, MRI imaging and histological characteristics of biopsy samples of the tendon from patients in whom rotator cuff repair was previously performed with a bioinductive type I bovine collagen implants. Prospective study of 30 patients with partial or complete rotator cuff tears who underwent arthroscopic repair and augmentation with a resorbable type I bovine collagen implant. Preoperatively and at 6 and 12 months after surgery, the VAS, ASES and Constant-Murley scores were evaluated and an MRI study was performed. At 6 months, biopsies of the resulting tissue were obtained and examined histologically. Patients experienced statistically significant and sustained improvement from baseline for all scores and the mean tendon thickness increased by 1.84 mm. Magnetic resonance imaging evidence of complete healing was found in 27 patients and a considerable reduction in defect size, greater than 50%, was shown in 3. In all samples obtained, the new tissue generated had the histological appearance of a tendon, and was indistinguishable from the native tendon. There was no evidence of any remaining collagen implant. Biopsies of tissue formed from bioinductive type I bovine collagen implants showed, six months after surgery, the generation of a neotendon indistinguishable from the native one. Histology and MRI imaging, revealed complete integration of the implant and absence of inflammatory or foreign body reactions. The clinical parameters, thickness and MRI signal of the tendon improved significantly at 6 months, regardless of the type and size of the tear, and remained unchanged until 12 months. Level IV, case series.

中文翻译：

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生物诱导胶原蛋白植入物促进肩袖撕裂中的肌腱再生

为了评估临床结果、MRI 成像和肌腱活检样本的组织学特征，这些样本来自之前使用生物感应 I 型牛胶原植入物进行肩袖修复的患者。对 30 名部分或完全肩袖撕裂患者进行的前瞻性研究，这些患者接受了关节镜修复和可吸收 I 型牛胶原植入物增强。术前和术后 6 个月和 12 个月，评估 VAS、ASES 和 Constant-Murley 评分并进行 MRI 研究。在 6 个月时，获得所得组织的活组织检查并进行组织学检查。患者的所有评分均较基线有统计学意义且持续改善，平均肌腱厚度增加 1.84 毫米。在 27 名患者中发现了完全愈合的磁共振成像证据，其中 3 名患者的缺损尺寸显着减少，超过 50%。在获得的所有样本中，生成的新组织具有肌腱的组织学外观，并且无法区分来自原生肌腱。没有任何剩余胶原蛋白植入物的证据。由生物诱导型 I 型牛胶原蛋白植入物形成的组织活检显示，手术六个月后，新肌腱的生成与天然肌腱无法区分。组织学和 MRI 成像显示植入物完全整合，没有炎症或异物反应。肌腱的临床参数、厚度和 MRI 信号在 6 个月时显着改善，无论撕裂的类型和大小如何，直到 12 个月都保持不变。