James Olzmann discusses the groundbreaking work of Ron Kopito and colleagues, which demonstrated that a CFTR mutant is ubiquitinated and degraded by the cytosolic 26S proteasome. This discovery contributed to our understanding of ERAD and had important implications for the development of therapeutic agents for cystic fibrosis.

中文翻译：

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路的尽头：从 ER 到蛋白酶体

James Olzmann 讨论了 Ron Kopito 及其同事的开创性工作，该工作表明 CFTR 突变体被胞质 26S 蛋白酶体泛素化和降解。这一发现有助于我们了解 ERAD，并对囊性纤维化治疗剂的开发具有重要意义。