Surgical management and outcome of Extra-adrenal myelolipomas at unusual locations: A report of 11 cases in a single center,Journal of Bone Oncology

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Surgical management and outcome of Extra-adrenal myelolipomas at unusual locations: A report of 11 cases in a single center
Journal of Bone Oncology ( IF 3.1 ) Pub Date : 2022-06-07 , DOI: 10.1016/j.jbo.2022.100438
Jiashi Cao _{1,

2} , Xing Huang ₂ , Na Cui ₃ , Xiang Wang ₄ , Chaoqun You _{2,

5} , Xiangzhi Ni ₂ , Xin Gao ₂ , Jing Wang ₂ , Tielong Liu ₂

Affiliation

Purpose

Extra-adrenal myelolipomas (EAMs) are rare benign tumors composed of both mature adipose and hematopoietic tissues with unclear etiology. There have been only sporadic case reports about the clinical characteristics and management of EAMs. Here we present our experience and practice in the clinical diagnosis and treatment of 11 consecutive patients with EAMs.

Method

We retrospectively reviewed 11 consecutive patients, who received surgeries in our department and were confirmed as having EAMs by postoperative histopathology from April 2016 to December 2021. Clinical information and follow-up data of all patients were collected and analyzed afterwards.

Results

Of the 11 EAM patients (7 male and 4 female) with a mean age of 47.6 years, 3 were asymptomatic and 8 were symptomatic with a mean symptom duration of 6.07 months. EAMs were found in the thoracic spine in 4 cases, paravertebral mediastinal regions in 3 cases, ilium in 2 cases, humerus in 1 case, and rib in 1 case. All patients were initially misdiagnosed as other tumors by radiologists. All 11 patients received gross total excision or curettage with a mean intraoperative blood loss of 781.82 ± 1143.3 ml and a mean operation duration of 180.91 ± 98.41 min. Patients’ Frankel scores and Karnofsky Performance Status score were improved or at least preserved postoperatively. No significant complications occurred postoperatively. All the 11 patients survived, and no local recurrence or distant metastasis occurred during the mean follow-up period of 42.0 months.

Conclusion

The surgical outcome and prognosis of EAMs are excellent and surgery can serve as the method of radical treatment.

中文翻译：

异常部位肾上腺外骨髓脂肪瘤的手术治疗和结果：单中心11例报告

目的

肾上腺外骨髓脂肪瘤（EAMs）是一种罕见的良性肿瘤，由成熟的脂肪和造血组织组成，病因不明。关于 EAM 的临床特征和管理，只有零星的病例报告。在这里，我们介绍了我们在连续 11 例 EAM 患者的临床诊断和治疗中的经验和实践。

方法

我们回顾性分析了2016年4月至2021年12月在我科接受手术并经术后组织病理学证实为EAMs的11例患者。收集并分析所有患者的临床资料和随访资料。

结果

11 例 EAM 患者（7 男 4 女）平均年龄 47.6 岁，其中 3 例无症状，8 例有症状，平均症状持续时间为 6.07 个月。胸椎4例，椎旁纵隔3例，髂骨2例，肱骨1例，肋骨1例。所有患者最初都被放射科医生误诊为其他肿瘤。所有 11 例患者均接受了全切或刮除术，平均术中失血量为 781.82 ± 1143.3 ml，平均手术时间为 180.91 ± 98.41 分钟。患者的 Frankel 评分和 Karnofsky 体能状态评分在术后得到改善或至少保持不变。术后无明显并发症发生。11例患者全部存活，平均随访42例无局部复发或远处转移。