Arylations with nitroarenes for one-pot syntheses of triaryl-methanols and tetraarylmethanes,Organic Chemistry Frontiers

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Arylations with nitroarenes for one-pot syntheses of triaryl-methanols and tetraarylmethanes
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2022-06-07 , DOI: 10.1039/d2qo00576j
Jie Li _{1,

2} , Dong Zou _{1,

3} , Bo Wang ₄ , Ayşegül İşcan ₄ , Huimin Jin _{1,

2} , Lingfeng Chen ₁ , Fan Zhou _{1,

2} , Patrick J. Walsh ₄ , Guang Liang ₁

Affiliation

Triarylmethanols are well-known core structures in natural products and pharmacologically relevant compounds. In general, transition metal-based catalysts or highly reactive organometallics are employed for the synthesis of these compounds. Herein, we report the regioselective tandem C(sp³)–H arylation/oxidation of diarylmethanes with nitroarenes to generate arylated alcohols. The present method is general, mild, green, and conducted in air at room temperature. Furthermore, use of triarylmethanes as pro-nucleophiles provides straightforward access to select tetraarylmethanes through a cross-dehydrogenative coupling process.

中文翻译：

硝基芳烃芳基化一锅法合成三芳基甲醇和四芳基甲烷

三芳基甲醇是天然产物和药理学相关化合物中众所周知的核心结构。通常，过渡金属基催化剂或高反应性有机金属化合物用于合成这些化合物。在此，我们报道了二芳基甲烷与硝基芳烃的区域选择性串联 C(sp ³ )-H 芳基化/氧化生成芳基化醇。本方法是通用的、温和的、绿色的并且在室温下在空气中进行。此外，使用三芳基甲烷作为亲核试剂可以通过交叉脱氢偶联过程直接选择四芳基甲烷。

更新日期：2022-06-07

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